Concepedia

Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes

Jill C. Milne, Philip Lambert, Simon Schenk, David P. Carney, J. Joshua Smith, David Gagné, Lei Jin, Olivier Boss, Robert B. Perni, Chi B. Vu,

Nature · 2007 · 1.7K citations · 25 references

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25

Resveratrol improves health and survival of mice on a high-calorie diet

Joseph A. Baur, Kevin Pearson, Nathan L. Price et al. · Nature · 2006 · 4.2K citations · Full text

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Resveratrol Improves Mitochondrial Function and Protects against Metabolic Disease by Activating SIRT1 and PGC-1α

Marie Lagouge, Carmen Argmann, Zachary Gerhart‐Hines et al. · Cell · 2006 · 4K citations · Full text

, , +16

Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan

Konrad T. Howitz, Kevin J. Bitterman, Haim Cohen et al. · Nature · 2003 · 3.8K citations

, , +12

Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase

Shin‐ichiro Imai, Christopher M. Armstrong, Matt Kaeberlein et al. · Nature · 2000 · 3.5K citations

, , +16

Nutrient control of glucose homeostasis through a complex of PGC-1α and SIRT1

Joseph T. Rodgers, Carles Lerín, Wilhelm Haas et al. · Nature · 2005 · 3.1K citations

, , +14