Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes

Jill C. Milne, Philip Lambert, Simon Schenk, +25

Nature

Diabetes ManagementMedicineDiabetesType 2Small Molecule Activators +7

Selective Killing of Mixed Lineage Leukemia Cells by a Potent Small-Molecule DOT1L Inhibitor

Scott R. Daigle, Edward J. Olhava, Carly A. Therkelsen, +18

Cancer Cell

Hematological MalignancyTumor BiologySelective KillingMedicineMixed-phenotype Acute Leukemia +6

A selective inhibitor of EZH2 blocks H3K27 methylation and kills mutant lymphoma cells

Sarah K. Knutson, Tim J. Wigle, Natalie M. Warholic, +18

Nature Chemical Biology

Lymphoid NeoplasiaMedicineSelective InhibitorAnti-cancer AgentTumor Suppressor +6

Potent inhibition of DOT1L as treatment of MLL-fusion leukemia

Scott R. Daigle, Edward J. Olhava, Carly A. Therkelsen, +13

Blood

The anticoagulant activation of antithrombin by heparin

Lei Jin, Jan Pieter Abrahams, Richard Skinner, +3

Proceedings of the National Academy of Sciences

A selective inhibitor of PRMT5 with in vivo and in vitro potency in MCL models

Elayne Chan-Penebre, Kristy G. Kuplast, Christina R. Majer, +27

Nature Chemical Biology

Vitro PotencySignal TransductionMedicineMcl ModelsSelective Inhibitor +8

AG-221, a First-in-Class Therapy Targeting Acute Myeloid Leukemia Harboring Oncogenic <i>IDH2</i> Mutations

Katharine Yen, Jeremy Travins, Fang Wang, +37

Cancer Discovery

Bridging the NFAT and NF-κB Families

Cristina López-Rodrı́guez, J. Aramburu, Lei Jin, +3

Immunity

Nf-κb FamiliesProtein FunctionSystems Biology

Crystal structure of human calcineurin complexed with cyclosporin A and human cyclophilin

Lei Jin, Stephen C. Harrison

Proceedings of the National Academy of Sciences

Crystal Structures of Human SIRT3 Displaying Substrate-induced Conformational Changes

Lei Jin, Wentao Wei, Yaobin Jiang, +10

Journal of Biological Chemistry

Protein ChemistryAldo-keto ReductaseBiochemistryProtein FoldingHuman Sirt3 +11