Edward J. Olhava

An inhibitor of NEDD8-activating enzyme as a new approach to treat cancer

Teresa A. Soucy, Peter G. Smith, Michael A. Milhollen et al. · Nature · 2009 · 2K citations

Medicine, Medicinal Chemistry, Oncology +8

Selective Killing of Mixed Lineage Leukemia Cells by a Potent Small-Molecule DOT1L Inhibitor

Scott R. Daigle, Edward J. Olhava, Carly A. Therkelsen et al. · Cancer Cell · 2011 · 934 citations · Full text

Medicine, Medicinal Chemistry, Oncology +10

A selective inhibitor of EZH2 blocks H3K27 methylation and kills mutant lymphoma cells

Sarah K. Knutson, Tim J. Wigle, Natalie M. Warholic et al. · Nature Chemical Biology · 2012 · 761 citations

Medicine, Molecular Biology, Oncology +12

Potent inhibition of DOT1L as treatment of MLL-fusion leukemia

Scott R. Daigle, Edward J. Olhava, Carly A. Therkelsen et al. · Blood · 2013 · 725 citations · Full text

Medicine, Oncology, Pharmacology +11

Enantioselective Synthesis of Dihydropyrans. Catalysis of Hetero Diels−Alder Reactions by Bis(oxazoline) Copper(II) Complexes

David A. Evans, Jeffrey S. Johnson, Edward J. Olhava · Journal of the American Chemical Society · 2000 · 318 citations

Natural Sciences, Chemistry, Catalysis +13