Sarah K. Knutson

Durable tumor regression in genetically altered malignant rhabdoid tumors by inhibition of methyltransferase EZH2

Sarah K. Knutson, Natalie M. Warholic, Tim J. Wigle et al. · Proceedings of the National Academy of Sciences · 2013 · 782 citations · Full text

Medicine, Oncology, Pharmacology +16

A selective inhibitor of EZH2 blocks H3K27 methylation and kills mutant lymphoma cells

Sarah K. Knutson, Tim J. Wigle, Natalie M. Warholic et al. · Nature Chemical Biology · 2012 · 761 citations

Medicine, Molecular Biology, Oncology +12

Coordinated activities of wild-type plus mutant EZH2 drive tumor-associated hypertrimethylation of lysine 27 on histone H3 (H3K27) in human B-cell lymphomas

Christopher J. Sneeringer, Margaret Porter Scott, Kevin W. Kuntz et al. · Proceedings of the National Academy of Sciences · 2010 · 680 citations · Full text

Life Sciences, Genetics, Molecular Biology +17

Selective Inhibition of EZH2 by EPZ-6438 Leads to Potent Antitumor Activity in <i>EZH2</i> -Mutant Non-Hodgkin Lymphoma

Sarah K. Knutson, Satoshi Kawano, Yukinori Minoshima et al. · Molecular Cancer Therapeutics · 2014 · 522 citations

Medicine, Oncology, Pharmacology +14

Loss of BAP1 function leads to EZH2-dependent transformation

Lindsay M. LaFave, Wendy Béguelin, Richard P. Koche et al. · Nature Medicine · 2015 · 398 citations · Full text

Life Sciences, Cell Biology, Molecular Biology +7