Michael A. Milhollen

An inhibitor of NEDD8-activating enzyme as a new approach to treat cancer

Teresa A. Soucy, Peter G. Smith, Michael A. Milhollen et al. · Nature · 2009 · 2K citations

Novel Therapy, Medicine, New Approach +9

Substrate-Assisted Inhibition of Ubiquitin-like Protein-Activating Enzymes: The NEDD8 E1 Inhibitor MLN4924 Forms a NEDD8-AMP Mimetic In Situ

James E. Brownell, Michael D. Sintchak, James M. Gavin et al. · Molecular Cell · 2010 · 457 citations · Full text

Protein Chemistry, Nedd8-amp Mimetic, Protein Function +7

A small-molecule inhibitor of the ubiquitin activating enzyme for cancer treatment

Marc L. Hyer, Michael A. Milhollen, Jeff Ciavarri et al. · Nature Medicine · 2018 · 414 citations

Medicine, Anti-cancer Agent, Small-molecule Inhibitor +8

Identification of <scp>d</scp> -Peptide Ligands Through Mirror-Image Phage Display

Ton N. Schumacher, Lorenz M. Mayr, Daniel L. Minor et al. · Science · 1996 · 368 citations

MLN4924, a NEDD8-activating enzyme inhibitor, is active in diffuse large B-cell lymphoma models: rationale for treatment of NF-κB–dependent lymphoma

Michael A. Milhollen, Tary Traore, Jennifer Adams-Duffy et al. · Blood · 2010 · 320 citations · Full text