Marc L. Hyer

A small-molecule inhibitor of the ubiquitin activating enzyme for cancer treatment

Marc L. Hyer, Michael A. Milhollen, Jeff Ciavarri et al. · Nature Medicine · 2018 · 456 citations

Pharmacy, Medicinal Chemistry, Oncology +14

Characterization of Alisertib (MLN8237), an Investigational Small-Molecule Inhibitor of Aurora A Kinase Using Novel <i>In Vivo</i> Pharmacodynamic Assays

Mark Manfredi, Jeffrey Ecsedy, Arijit Chakravarty et al. · Clinical Cancer Research · 2011 · 302 citations

Medicine, Oncology, Pharmacology +14

MAT2A Inhibition Blocks the Growth of MTAP-Deleted Cancer Cells by Reducing PRMT5-Dependent mRNA Splicing and Inducing DNA Damage

Peter Kalev, Marc L. Hyer, Zenon Konteatis et al. · Cancer Cell · 2021 · 234 citations

Life Sciences, Molecular Biology, Oncology +7

Synthetic Triterpenoids Cooperate with Tumor Necrosis Factor–Related Apoptosis-Inducing Ligand to Induce Apoptosis of Breast Cancer Cells

Marc L. Hyer, Rhonda Croxton, Maryla Krajewska et al. · Cancer Research · 2005 · 127 citations · Full text

Life Sciences, Oncology, Pharmacology +15

MLN8054, an Inhibitor of Aurora A Kinase, Induces Senescence in Human Tumor Cells Both <i>In vitro</i> and <i>In vivo</i>

Jessica J. Huck, Mengkun Zhang, Alice McDonald et al. · Molecular Cancer Research · 2010 · 117 citations

Life Sciences, Cell Biology, Pharmacology +14