Zenon Konteatis

AG-221, a First-in-Class Therapy Targeting Acute Myeloid Leukemia Harboring Oncogenic <i>IDH2</i> Mutations

Katharine Yen, Jeremy Travins, Fang Wang et al. · Cancer Discovery · 2017 · 444 citations · Full text

MTAP Deletions in Cancer Create Vulnerability to Targeting of the MAT2A/PRMT5/RIOK1 Axis

Katya Marjon, Michael J. Cameron, Phong Quang et al. · Cell Reports · 2016 · 415 citations · Full text

Acquired resistance to IDH inhibition through trans or cis dimer-interface mutations

Andrew M. Intlekofer, Alan H. Shih, Bo Wang et al. · Nature · 2018 · 271 citations · Full text

Somatic Variant, Genetics, Dimer-interface Mutations +8

Two-site binding of C5a by its receptor: analternative binding paradigm for G protein-coupled receptors.

Salvatore Siciliano, Thomas E. Rollins, Julie A. DeMartino et al. · Proceedings of the National Academy of Sciences · 1994 · 235 citations · Full text

Molecular Biology, Receptor N Terminus, Analternative Binding Paradigm +19

MAT2A Inhibition Blocks the Growth of MTAP-Deleted Cancer Cells by Reducing PRMT5-Dependent mRNA Splicing and Inducing DNA Damage

Peter Kalev, Marc L. Hyer, Zenon Konteatis et al. · Cancer Cell · 2021 · 214 citations

Medicine, Cancer Growth, Cancer Cell Biology +9