Jessica J. Huck

A small-molecule inhibitor of the ubiquitin activating enzyme for cancer treatment

Marc L. Hyer, Michael A. Milhollen, Jeff Ciavarri et al. · Nature Medicine · 2018 · 414 citations

Medicine, Anti-cancer Agent, Small-molecule Inhibitor +8

Antitumor activity of MLN8054, an orally active small-molecule inhibitor of Aurora A kinase

Mark Manfredi, Jeffrey Ecsedy, Kristan Meetze et al. · Proceedings of the National Academy of Sciences · 2007 · 413 citations · Full text

Tumor Biology, Active Small-molecule Inhibitor, Antitumor Activity +15

Characterization of Alisertib (MLN8237), an Investigational Small-Molecule Inhibitor of Aurora A Kinase Using Novel <i>In Vivo</i> Pharmacodynamic Assays

Mark Manfredi, Jeffrey Ecsedy, Arijit Chakravarty et al. · Clinical Cancer Research · 2011 · 298 citations

MLN8054, an Inhibitor of Aurora A Kinase, Induces Senescence in Human Tumor Cells Both <i>In vitro</i> and <i>In vivo</i>

Jessica J. Huck, Mengkun Zhang, Alice McDonald et al. · Molecular Cancer Research · 2010 · 117 citations

Cancer Research, Aurora A Kinase, Cell Regulation +14

MLN8054 and Alisertib (MLN8237): Discovery of Selective Oral Aurora A Inhibitors

Todd B. Sells, Ryan Chau, Jeffrey Ecsedy et al. · ACS Medicinal Chemistry Letters · 2015 · 108 citations · Full text

Aurora A, Immunology, Molecular Biology +19