Ryan Chau

Probing the roles of SUMOylation in cancer cell biology by using a selective SAE inhibitor

Xingyue He, Jessica Riceberg, Teresa A. Soucy et al. · Nature Chemical Biology · 2017 · 229 citations

Medicine, Cancer Biology, Molecular Biology +8

Discovery of TAK-981, a First-in-Class Inhibitor of SUMO-Activating Enzyme for the Treatment of Cancer

Steven Langston, Stephen Grossman, Dylan B. England et al. · Journal of Medicinal Chemistry · 2021 · 208 citations · Full text

Pharmacy, Medicinal Chemistry, Oncology +11

MLN8054 and Alisertib (MLN8237): Discovery of Selective Oral Aurora A Inhibitors

Todd B. Sells, Ryan Chau, Jeffrey Ecsedy et al. · ACS Medicinal Chemistry Letters · 2015 · 111 citations · Full text

Medicine, Oncology, Pharmacology +14

Discovery of a Potent and Orally Bioavailable Benzolactam-Derived Inhibitor of Polo-Like Kinase 1 (MLN0905)

Matthew O. Duffey, Tricia J. Vos, Ruth Adams et al. · Journal of Medicinal Chemistry · 2011 · 56 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +14

Novel Indole Chemistry in the Synthesis of Heterocycles

Gordon W. Gribble, Mark G. Saulnier, Erin T. Pelkey et al. · Current Organic Chemistry · 2005 · 45 citations

Natural Sciences, Chemistry, Medicinal Chemistry +15