Concepedia

Steven Langston

SL

Statistics

Publications

20

Citations

4.4K

H-Index

17

Active since

1990

Affiliations

Takeda (United States)(Current)

Millennium Engineering and Integration (United States)

Massachusetts Institute of Technology

University of Sheffield

Steven Langston is an author at Takeda (United States) specializing in drug discovery, molecular oncology, and enzyme inhibition.

ORCID

Publications per year

1990–2023

20

Publications

20

An inhibitor of NEDD8-activating enzyme as a new approach to treat cancer

Teresa A. Soucy, Peter G. Smith, Michael A. Milhollen et al. · Nature · 2009 · 2K citations

, , +8

Substrate-Assisted Inhibition of Ubiquitin-like Protein-Activating Enzymes: The NEDD8 E1 Inhibitor MLN4924 Forms a NEDD8-AMP Mimetic In Situ

James E. Brownell, Michael D. Sintchak, James M. Gavin et al. · Molecular Cell · 2010 · 461 citations · Full text

, , +16

A small-molecule inhibitor of the ubiquitin activating enzyme for cancer treatment

Marc L. Hyer, Michael A. Milhollen, Jeff Ciavarri et al. · Nature Medicine · 2018 · 456 citations

, , +14

MLN4924, a NEDD8-activating enzyme inhibitor, is active in diffuse large B-cell lymphoma models: rationale for treatment of NF-κB–dependent lymphoma

Michael A. Milhollen, Tary Traore, Jennifer Adams-Duffy et al. · Blood · 2010 · 323 citations · Full text

, , +11

Probing the roles of SUMOylation in cancer cell biology by using a selective SAE inhibitor

Xingyue He, Jessica Riceberg, Teresa A. Soucy et al. · Nature Chemical Biology · 2017 · 229 citations

, , +8

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