Michael D. Sintchak

An inhibitor of NEDD8-activating enzyme as a new approach to treat cancer

Teresa A. Soucy, Peter G. Smith, Michael A. Milhollen et al. · Nature · 2009 · 2K citations

Medicine, Medicinal Chemistry, Oncology +8

Substrate-Assisted Inhibition of Ubiquitin-like Protein-Activating Enzymes: The NEDD8 E1 Inhibitor MLN4924 Forms a NEDD8-AMP Mimetic In Situ

James E. Brownell, Michael D. Sintchak, James M. Gavin et al. · Molecular Cell · 2010 · 461 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +16

A small-molecule inhibitor of the ubiquitin activating enzyme for cancer treatment

Marc L. Hyer, Michael A. Milhollen, Jeff Ciavarri et al. · Nature Medicine · 2018 · 456 citations

Pharmacy, Medicinal Chemistry, Oncology +14

Structure and Mechanism of Inosine Monophosphate Dehydrogenase in Complex with the Immunosuppressant Mycophenolic Acid

Michael D. Sintchak, Mark Fleming, Olga Futer et al. · Cell · 1996 · 421 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +12

Life on carbon monoxide: X-ray structure of <i>Rhodospirillum rubrum</i> Ni-Fe-S carbon monoxide dehydrogenase

Catherine L. Drennan, Jongyun Heo, Michael D. Sintchak et al. · Proceedings of the National Academy of Sciences · 2001 · 312 citations · Full text

Life Sciences, Biochemistry, Biology +15