Todd B. Sells

Substrate-Assisted Inhibition of Ubiquitin-like Protein-Activating Enzymes: The NEDD8 E1 Inhibitor MLN4924 Forms a NEDD8-AMP Mimetic In Situ

James E. Brownell, Michael D. Sintchak, James M. Gavin et al. · Molecular Cell · 2010 · 461 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +16

Antitumor activity of MLN8054, an orally active small-molecule inhibitor of Aurora A kinase

Mark Manfredi, Jeffrey Ecsedy, Kristan Meetze et al. · Proceedings of the National Academy of Sciences · 2007 · 413 citations · Full text

Medicine, Oncology, Pharmacology +14

Characterization of Alisertib (MLN8237), an Investigational Small-Molecule Inhibitor of Aurora A Kinase Using Novel <i>In Vivo</i> Pharmacodynamic Assays

Mark Manfredi, Jeffrey Ecsedy, Arijit Chakravarty et al. · Clinical Cancer Research · 2011 · 302 citations

Medicine, Oncology, Pharmacology +14

MLN8054 and Alisertib (MLN8237): Discovery of Selective Oral Aurora A Inhibitors

Todd B. Sells, Ryan Chau, Jeffrey Ecsedy et al. · ACS Medicinal Chemistry Letters · 2015 · 111 citations · Full text

Medicine, Oncology, Pharmacology +14

Treatment-Emergent Mutations in NAEβ Confer Resistance to the NEDD8-Activating Enzyme Inhibitor MLN4924

Michael A. Milhollen, Michael P. Thomas, Usha Narayanan et al. · Cancer Cell · 2012 · 110 citations · Full text

Life Sciences, Genetics, Molecular Biology +7