Usha Narayanan

An inhibitor of NEDD8-activating enzyme as a new approach to treat cancer

Teresa A. Soucy, Peter G. Smith, Michael A. Milhollen et al. · Nature · 2009 · 2K citations

Novel Therapy, Medicine, New Approach +9

MLN4924, a NEDD8-activating enzyme inhibitor, is active in diffuse large B-cell lymphoma models: rationale for treatment of NF-κB–dependent lymphoma

Michael A. Milhollen, Tary Traore, Jennifer Adams-Duffy et al. · Blood · 2010 · 320 citations · Full text

NEDD8-Targeting Drug MLN4924 Elicits DNA Rereplication by Stabilizing Cdt1 in S Phase, Triggering Checkpoint Activation, Apoptosis, and Senescence in Cancer Cells

Jie Lin, Michael A. Milhollen, Peter G. Smith et al. · Cancer Research · 2010 · 290 citations · Full text

Mln4924-induced Cell Senescence, Genome Instability, Cell Regulation +13

Fragile X mental retardation protein deficiency leads to excessive mGluR5-dependent internalization of AMPA receptors

M. Nakamoto, Vijayalaxmi Nalavadi, Michael P. Epstein et al. · Proceedings of the National Academy of Sciences · 2007 · 245 citations · Full text

Neurotransmitter, Molecular Biology, Mglur5-dependent Internalization +20

FMRP Phosphorylation Reveals an Immediate-Early Signaling Pathway Triggered by Group I mGluR and Mediated by PP2A

Usha Narayanan, Vijayalaxmi Nalavadi, M. Nakamoto et al. · Journal of Neuroscience · 2007 · 224 citations · Full text