Carly A. Therkelsen

Selective Killing of Mixed Lineage Leukemia Cells by a Potent Small-Molecule DOT1L Inhibitor

Scott R. Daigle, Edward J. Olhava, Carly A. Therkelsen et al. · Cancer Cell · 2011 · 923 citations · Full text

Hematological Malignancy, Tumor Biology, Selective Killing +8

Potent inhibition of DOT1L as treatment of MLL-fusion leukemia

Scott R. Daigle, Edward J. Olhava, Carly A. Therkelsen et al. · Blood · 2013 · 718 citations · Full text

Conformational Adaptation Drives Potent, Selective and Durable Inhibition of the Human Protein Methyltransferase DOT1L

Aravind Basavapathruni, Lei Jin, Scott R. Daigle et al. · Chemical Biology & Drug Design · 2012 · 141 citations · Full text

Nonclinical pharmacokinetics and metabolism of EPZ‐5676, a novel DOT1L histone methyltransferase inhibitor

Aravind Basavapathruni, Edward J. Olhava, Scott R. Daigle et al. · Biopharmaceutics & Drug Disposition · 2014 · 74 citations

Selective Killing of Mixed Lineage Leukemia Cells by a Potent Small-Molecule DOT1L Inhibitor

Roy M. Pollock, Scott R. Daigle, Edward J. Olhava et al. · Blood · 2010 · 10 citations