Roy M. Pollock

Isolation and properties of cDNA clones encoding SRF, a transcription factor that binds to the c-fos serum response element

Christine M. Norman, M J Runswick, Roy M. Pollock et al. · Cell · 1988 · 990 citations

Transcriptional Regulation, Signal Transduction, Protein Expression +11

Selective Killing of Mixed Lineage Leukemia Cells by a Potent Small-Molecule DOT1L Inhibitor

Scott R. Daigle, Edward J. Olhava, Carly A. Therkelsen et al. · Cancer Cell · 2011 · 923 citations · Full text

Hematological Malignancy, Tumor Biology, Selective Killing +8

MLL-Rearranged Leukemia Is Dependent on Aberrant H3K79 Methylation by DOT1L

Kathrin M. Bernt, Nan Zhu, Amit Sinha et al. · Cancer Cell · 2011 · 883 citations · Full text

Hematological Malignancy, Tumor Biology, Chromatin +9

Durable tumor regression in genetically altered malignant rhabdoid tumors by inhibition of methyltransferase EZH2

Sarah K. Knutson, Natalie M. Warholic, Tim J. Wigle et al. · Proceedings of the National Academy of Sciences · 2013 · 757 citations · Full text

Engineering, Chemoprevention Strategy, Smarcb1-deleted Mrt Cells +24

A selective inhibitor of EZH2 blocks H3K27 methylation and kills mutant lymphoma cells

Sarah K. Knutson, Tim J. Wigle, Natalie M. Warholic et al. · Nature Chemical Biology · 2012 · 753 citations

Lymphoid Neoplasia, Medicine, Selective Inhibitor +8