Roy M. Pollock

Isolation and properties of cDNA clones encoding SRF, a transcription factor that binds to the c-fos serum response element

Christine M. Norman, M J Runswick, Roy M. Pollock et al. · Cell · 1988 · 991 citations

Life Sciences, Genetics, Molecular Biology +10

Selective Killing of Mixed Lineage Leukemia Cells by a Potent Small-Molecule DOT1L Inhibitor

Scott R. Daigle, Edward J. Olhava, Carly A. Therkelsen et al. · Cancer Cell · 2011 · 934 citations · Full text

Medicine, Medicinal Chemistry, Oncology +10

MLL-Rearranged Leukemia Is Dependent on Aberrant H3K79 Methylation by DOT1L

Kathrin M. Bernt, Nan Zhu, Amit Sinha et al. · Cancer Cell · 2011 · 893 citations · Full text

Medicine, Molecular Genetics, Oncology +13

Durable tumor regression in genetically altered malignant rhabdoid tumors by inhibition of methyltransferase EZH2

Sarah K. Knutson, Natalie M. Warholic, Tim J. Wigle et al. · Proceedings of the National Academy of Sciences · 2013 · 782 citations · Full text

Medicine, Oncology, Pharmacology +16

A selective inhibitor of EZH2 blocks H3K27 methylation and kills mutant lymphoma cells

Sarah K. Knutson, Tim J. Wigle, Natalie M. Warholic et al. · Nature Chemical Biology · 2012 · 761 citations

Medicine, Molecular Biology, Oncology +12