MLL-Rearranged Leukemia Is Dependent on Aberrant H3K79 Methylation by DOT1L

Kathrin M. Bernt, Nan Zhu, Amit Sinha, +11

Cancer Cell

Hematological MalignancyTumor BiologyChromatinEpigenetic ChangeCancer Cell Biology +7

Long noncoding RNA high expression in hepatocellular carcinoma facilitates tumor growth through enhancer of zeste homolog 2 in humans

Fu Yang, Ling Zhang, Xisong Huo, +12

Hepatology

Chromatin-modifying enzymes as modulators of reprogramming

Tamer T. Önder, Nergis Kara, Anne Cherry, +10

Nature

Histone ModificationsChromatinTranscriptional RegulationChromatin RemodelingNatural Sciences +8

DOT1L inhibits SIRT1-mediated epigenetic silencing to maintain leukemic gene expression in MLL-rearranged leukemia

Chun‐Wei Chen, Richard P. Koche, Amit Sinha, +14

Nature Medicine

Hematological MalignancyTumor BiologyChromatinMll-rearranged LeukemiaEpigenetic Regulation +9

Polycomb repressive complex 2 is required for MLL-AF9 leukemia

Tobias Neff, Amit Sinha, Michael Kluk, +6

Proceedings of the National Academy of Sciences

CDK9-mediated transcription elongation is required for MYC addiction in hepatocellular carcinoma

Chun‐Hao Huang, Amaia Lujambio, Johannes Zuber, +11

Genes & Development

AF10 Regulates Progressive H3K79 Methylation and HOX Gene Expression in Diverse AML Subtypes

Aniruddha J. Deshpande, Anagha Deshpande, Amit Sinha, +17

Cancer Cell

Hox Gene ExpressionDiverse Aml SubtypesEpigenetic ChangeGeneticsEpigenomics +5

Notch pathway activation targets AML-initiating cell homeostasis and differentiation

Camille Lobry, Panagiotis Ntziachristos, Delphine Ndiaye‐Lobry, +13

The Journal of Experimental Medicine

Mixed-phenotype Acute LeukemiaImmunologyTumor BiologyMyeloid NeoplasiaHematological Malignancy +14

Haploinsufficiency of <i>Dnmt1</i> impairs leukemia stem cell function through derepression of bivalent chromatin domains

Jennifer J. Trowbridge, Amit Sinha, Nan Zhu, +3

Genes & Development

Histone ModificationsMixed-phenotype Acute LeukemiaGeneticsEpigenetic ChangeEpigenetics +18

Repression of lncRNA NEAT1 enhances the antitumor activity of CD8+T cells against hepatocellular carcinoma via regulating miR-155/Tim-3

Kai Yan, Yong Fu, Nan Zhu, +6

The International Journal of Biochemistry & Cell Biology