Concepedia

Sirtuin 1 Regulation

Sirtuin 1 Regulation is a molecular regulatory mechanism that modulates gluconeogenesis through the deacetylation of key transcription factors and coactivators, particularly by enhancing the activity of peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1α) in response to cellular energy status.

2.9K

Publications

247.6K

Citations

17.7K

Authors

2.9K

Institutions

Publications per year

2017–2026

1.5K

Parents

Publications

2.9K

PGC-1α-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes

Vamsi K. Mootha, Cecilia M. Lindgren, Karl‐Fredrik Eriksson et al. · Nature Genetics · 2003 · 10.6K citations

, , +16

Resveratrol Improves Mitochondrial Function and Protects against Metabolic Disease by Activating SIRT1 and PGC-1α

Marie Lagouge, Carmen Argmann, Zachary Gerhart‐Hines et al. · Cell · 2006 · 4K citations · Full text

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Stress-Dependent Regulation of FOXO Transcription Factors by the SIRT1 Deacetylase

Anne Brunet, Lora B. Sweeney, James Fitzhugh Sturgill et al. · Science · 2004 · 3.2K citations

, , +15

Nutrient control of glucose homeostasis through a complex of PGC-1α and SIRT1

Joseph T. Rodgers, Carles Lerín, Wilhelm Haas et al. · Nature · 2005 · 3.1K citations

, , +14

Modulation of NF‐κB‐dependent transcription and cell survival by the SIRT1 deacetylase

Fan Yeung, Jamie E. Hoberg, C S Ramsey et al. · The EMBO Journal · 2004 · 2.7K citations · Full text

, , +16

1–5 of 2.9K

Authors

17.7K

  1. MW
    Michael W. McBurney

    University of Ottawa, Canada

    30 publications · 8.2K citations

    30

    h-index

  2. LG
    Leonard Guarente

    Massachusetts Institute of Technology, United States

    28 publications · 10.3K citations

    26

    h-index

  3. DL
    De‐Pei Liu

    Chinese Academy of Medical Sciences & Peking Union Medical College, China

    22 publications · 2.1K citations

    21

    h-index

  4. DS
    David Sinclair

    Harvard University, United States

    27 publications · 12.1K citations

    21

    h-index

  5. HC
    Hou‐Zao Chen

    Chinese Academy of Medical Sciences & Peking Union Medical College, China

    18 publications · 2K citations

    18

    h-index

1–5 of 17.7K

Institutions

2.9K

  1. Harvard University

    Cambridge, United States

    54 h-index

    267 publications

    228.6K citations

  2. National Institutes of Health

    Bethesda, United States

    41 h-index

    260 publications

    66.9K citations

  3. Chinese Academy of Medical Sciences & Peking Union Medical College

    Beijing, China

    34 h-index

    439 publications

    33.9K citations

  4. Sun Yat-sen University

    Guangzhou, China

    34 h-index

    296 publications

    18.4K citations

  5. Inserm

    Paris, France

    33 h-index

    257 publications

    38.9K citations

  6. Massachusetts Institute of Technology

    Cambridge, United States

    33 h-index

    104 publications

    54K citations

  7. Shanghai Jiao Tong University

    Shanghai, China

    30 h-index

    246 publications

    11.5K citations

  8. Nanjing Medical University

    Nanjing, China

    29 h-index

    221 publications

    10.9K citations

1–8 of 2.9K

Venues

  1. Journal of Biological Chemistry

    JBC · 74 publications · 15.5K citations

    58

    h-index

  2. PLoS ONE

    79 publications · 6.8K citations

    45

    h-index

  3. Biochemical and Biophysical Research Communications

    BBRC · 76 publications · 4.5K citations

    43

    h-index

  4. Scientific Reports

    55 publications · 3.7K citations

    35

    h-index

  5. Molecular Medicine Reports

    MMR · 68 publications · 2.5K citations

    31

    h-index

1–5