Leonard Guarente - Concepedia

Author

Leonard Guarente

Massachusetts Institute of Technology ORCID

Also Known As

Guarente, Leonard, Guarente, Leonard Pershing, Krainc, Dimitri, L GUARENTE, L Guarente, L. Guarente, Leonard GUARENTE, Leonard Guarente, Leonard P Guarente, Leonard P. Guarente

264

Publications

70.6K

Citations

116

H-Index

167

Concepts

All Affiliations

Massachusetts Institute of Technology Harvard University Massachusetts General Hospital Brigham and Women's Hospital Howard Hughes Medical Institute

About

Leonard Guarente is an author at Massachusetts Institute of Technology specializing in medicine, cell biology, and gene expression.

Top Concepts

#	Concept	H-Index	Publications	Citations
1	Medicine	74	101	44.3K
2	Natural Sciences	40	49	13.7K
3	Health Sciences	9	9	2.8K
4	Engineering	2	2	832
5	Humanities	1	1	46

Leonard Guarente

157

Publications

55.2K

Citations

H-Index

Page 1

	Year	Citations
Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase Shin‐ichiro Imai, Christopher M. Armstrong, Matt Kaeberlein, Nature Histone ModificationsChromatinTranscriptional RegulationLifespan ExtensionChromatin Remodeling	2000	3.5K
hSIR2SIRT1 Functions as an NAD-Dependent p53 Deacetylase Homayoun Vaziri, Scott Dessain, Elinor Ng Eaton, Cell Transcriptional RegulationHsir2sirt1 FunctionsMolecular BiologyTumor SuppressorCancer Genetics	2001	2.6K
The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms Matt Kaeberlein, Mitch McVey, Leonard Guarente Genes & Development	1999	2.3K
Negative Control of p53 by Sir2α Promotes Cell Survival under Stress Jianyuan Luo, Anatoly Nikolaev, Shin‐ichiro Imai, Cell Cell RegulationCell SignalingApoptosisCell DeathCellular Senescence	2001	2.1K
Sirt1 promotes fat mobilization in white adipocytes by repressing PPAR-γ Frédéric Picard, Martin V. Kurtev, Namjin Chung, Nature Fat MobilizationSignal TransductionCell SignalingPhysiologyMetabolic Regulation	2004	1.9K
Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans Heidi A. Tissenbaum, Leonard Guarente Nature Lifespan ExtensionDevelopmental BiologyLongevityGeneticsGenomic Mechanism	2001	1.9K
Requirement of NAD and <i>SIR2</i> for Life-Span Extension by Calorie Restriction in <i>Saccharomyces cerevisiae</i> Su-Ju Lin, Pierre‐Antoine Defossez, Leonard Guarente Science Anti-agingGeneticsMolecular BiologyNicotinamide Adenine DinucleotideBiogerontology	2000	1.8K
Reductive glutamine metabolism by IDH1 mediates lipogenesis under hypoxia Christian M. Metallo, Paulo A. Gameiro, Eric L. Bell, Nature BiochemistryRedox RegulatorHypoxia (Medicine)MetabolismMedicine	2011	1.7K
Genomic Instability and Aging-like Phenotype in the Absence of Mammalian SIRT6 Raúl Mostoslavsky, Katrin F. Chua, David B. Lombard, Cell Lifespan ExtensionChromatinGenome InstabilityGeneticsAging-like Phenotype	2006	1.6K
Extrachromosomal rDNA Circles— A Cause of Aging in Yeast David Sinclair, Leonard Guarente Cell ChromatinGenome InstabilityChromosome DynamicsChromatin StructureChromatin Remodeling	1997	1.5K

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