Shin‐ichiro Imai

Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase

Shin‐ichiro Imai, Christopher M. Armstrong, Matt Kaeberlein et al. · Nature · 2000 · 3.5K citations

Life Sciences, Genetics, Molecular Biology +16

hSIR2SIRT1 Functions as an NAD-Dependent p53 Deacetylase

Homayoun Vaziri, Scott Dessain, Elinor Ng Eaton et al. · Cell · 2001 · 2.6K citations · Full text

Life Sciences, Genetics, Molecular Biology +8

Negative Control of p53 by Sir2α Promotes Cell Survival under Stress

Jianyuan Luo, Anatoly Nikolaev, Shin‐ichiro Imai et al. · Cell · 2001 · 2.1K citations · Full text

Life Sciences, Cell Biology, Molecular Biology +14

Nicotinamide Mononucleotide, a Key NAD+ Intermediate, Treats the Pathophysiology of Diet- and Age-Induced Diabetes in Mice

Jun Yoshino, Kathryn F. Mills, Myeong Jin Yoon et al. · Cell Metabolism · 2011 · 1.3K citations · Full text

Life Sciences, Biochemistry, Pharmacology +15

Circadian Clock Feedback Cycle Through NAMPT-Mediated NAD ⁺ Biosynthesis

Kathryn Moynihan Ramsey, Jun Yoshino, Cynthia S. Brace et al. · Science · 2009 · 1.1K citations · Full text

Life Sciences, Biochemistry, Molecular Biology +17