Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase

The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms

Matt Kaeberlein, Mitch McVey, Leonard Guarente · Genes & Development · 1999 · 2.3K citations · Full text

Life Sciences, Genetics, Molecular Genetics +9

Potent and specific inhibition of mammalian histone deacetylase both in vivo and in vitro by trichostatin A.

Minoru Yoshida, Masako Kijima, Motomu Akita et al. · Journal of Biological Chemistry · 1990 · 1.9K citations · Full text

Life Sciences, Molecular Biology, Pharmacology +17

A Mammalian Histone Deacetylase Related to the Yeast Transcriptional Regulator Rpd3p

Jack Taunton, Christian A. Hassig, Stuart L. Schreiber · Science · 1996 · 1.8K citations

Life Sciences, Biochemistry, Molecular Biology +10

Extrachromosomal rDNA Circles— A Cause of Aging in Yeast

David Sinclair, Leonard Guarente · Cell · 1997 · 1.5K citations · Full text

Life Sciences, Genetics, Molecular Genetics +13

Position effect at S. cerevisiae telomeres: Reversible repression of Pol II transcription

Daniel E. Gottschling, Oscar M. Aparicio, Barbara Billington et al. · Cell · 1990 · 1.3K citations

Life Sciences, Genetics, Molecular Biology +17