Concepedia

Histone Deacetylation

Histone Deacetylation is a post-translational histone modification characterized by the enzymatic removal of acetyl groups from lysine residues on histone tails, leading to chromatin condensation and transcriptional repression.

2.8K

Publications

266.2K

Citations

15K

Authors

2.5K

Institutions

Publications per year

2017–2026

517

Parents

Publications

2.8K

Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase

Shin‐ichiro Imai, Christopher M. Armstrong, Matt Kaeberlein et al. · Nature · 2000 · 3.5K citations

, , +16

Transcriptional repression by the methyl-CpG-binding protein MeCP2 involves a histone deacetylase complex

Xinsheng Nan, Huck‐Hui Ng, Colin A. Johnson et al. · Nature · 1998 · 3.4K citations

, , +16

Methylated DNA and MeCP2 recruit histone deacetylase to repress transcription

Peter Lloyd Jones, Gert Jan C. Veenstra, Paul A. Wade et al. · Nature Genetics · 1998 · 2.7K citations

, , +10

Loss of acetylation at Lys16 and trimethylation at Lys20 of histone H4 is a common hallmark of human cancer

Mario F. Fraga, Esteban Ballestar, Ana Villar‐Garea et al. · Nature Genetics · 2005 · 1.9K citations

, , +13

Potent and specific inhibition of mammalian histone deacetylase both in vivo and in vitro by trichostatin A.

Minoru Yoshida, Masako Kijima, Motomu Akita et al. · Journal of Biological Chemistry · 1990 · 1.9K citations · Full text

, , +17

1–5 of 2.8K

Authors

15K

  1. ES
    Edward Seto

    Moffitt Cancer Center, United States

    30 publications · 5.3K citations

    26

    h-index

  2. MY
    Minoru Yoshida

    The University of Tokyo, Japan

    28 publications · 4.8K citations

    23

    h-index

  3. GB
    Gerald Brosch

    Innsbruck Medical University, Austria

    23 publications · 1.6K citations

    22

    h-index

  4. CS
    Christian Seiser

    Medical University of Vienna, Austria

    20 publications · 3.4K citations

    20

    h-index

  5. AM
    Antonello Mai

    Sapienza University of Rome, Italy

    22 publications · 1.2K citations

    20

    h-index

1–5 of 15K

Institutions

2.5K

  1. Harvard University

    Cambridge, United States

    59 h-index

    339 publications

    53.1K citations

  2. Howard Hughes Medical Institute

    Chevy Chase, United States

    54 h-index

    198 publications

    70.2K citations

  3. National Institutes of Health

    Bethesda, United States

    41 h-index

    184 publications

    33.6K citations

  4. Inserm

    Paris, France

    37 h-index

    216 publications

    23.6K citations

  5. University of Pennsylvania

    Philadelphia, United States

    35 h-index

    152 publications

    26.2K citations

  6. Chinese Academy of Sciences

    Beijing, China

    35 h-index

    286 publications

    16.6K citations

  7. The University of Texas MD Anderson Cancer Center

    Houston, United States

    34 h-index

    192 publications

    17.1K citations

  8. Centre National de la Recherche Scientifique

    Paris, France

    33 h-index

    135 publications

    17.7K citations

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Venues

  1. Journal of Biological Chemistry

    JBC · 220 publications · 27.5K citations

    86

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  2. Molecular and Cellular Biology

    MCB · 88 publications · 12K citations

    63

    h-index

  3. Proceedings of the National Academy of Sciences

    PNAS · 61 publications · 14.5K citations

    51

    h-index

  4. Nucleic Acids Research

    52 publications · 4.6K citations

    38

    h-index

  5. Blood

    51 publications · 5.8K citations

    36

    h-index

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