Concepedia

Histone Deacetylases

Histone Deacetylases is an enzyme class that catalyzes the removal of acetyl groups from lysine residues on histone proteins, thereby modulating chromatin structure and gene expression.

5.3K

Publications

452.1K

Citations

27.1K

Authors

3.8K

Institutions

Publications per year

2017–2026

1.3K

Variants

Hdacs

Parents

Publications

5.3K

Lysine Acetylation Targets Protein Complexes and Co-Regulates Major Cellular Functions

Chunaram Choudhary, Chanchal Kumar, Florian Gnad et al. · Science · 2009 · 4K citations · Full text

, , +10

Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase

Shin‐ichiro Imai, Christopher M. Armstrong, Matt Kaeberlein et al. · Nature · 2000 · 3.5K citations

, , +16

Transcriptional repression by the methyl-CpG-binding protein MeCP2 involves a histone deacetylase complex

Xinsheng Nan, Huck‐Hui Ng, Colin A. Johnson et al. · Nature · 1998 · 3.4K citations

, , +16

HDAC6 is a microtubule-associated deacetylase

Charlotte Hubbert, Amaris R. Guardiola, Rong Shao et al. · Nature · 2002 · 2.4K citations

, , +5

Loss of acetylation at Lys16 and trimethylation at Lys20 of histone H4 is a common hallmark of human cancer

Mario F. Fraga, Esteban Ballestar, Ana Villar‐Garea et al. · Nature Genetics · 2005 · 1.9K citations

, , +13

1–5 of 5.3K

Authors

27.1K

  1. EN
    Eric N. Olson

    The University of Texas Southwestern Medical Center, United States

    41 publications · 11.6K citations

    41

    h-index

  2. ES
    Edward Seto

    Moffitt Cancer Center, United States

    49 publications · 9.2K citations

    39

    h-index

  3. MJ
    Manfred Jung

    University of Freiburg, Germany

    57 publications · 3.9K citations

    34

    h-index

  4. MY
    Minoru Yoshida

    The University of Tokyo, Japan

    44 publications · 8.4K citations

    34

    h-index

  5. GB
    Gerald Brosch

    Innsbruck Medical University, Austria

    41 publications · 2.9K citations

    33

    h-index

1–5 of 27.1K

Institutions

3.8K

  1. Harvard University

    Cambridge, United States

    87 h-index

    694 publications

    102.7K citations

  2. Howard Hughes Medical Institute

    Chevy Chase, United States

    67 h-index

    272 publications

    96.3K citations

  3. Inserm

    Paris, France

    56 h-index

    447 publications

    42K citations

  4. University of Pennsylvania

    Philadelphia, United States

    55 h-index

    294 publications

    48.5K citations

  5. The University of Texas Southwestern Medical Center

    Dallas, United States

    54 h-index

    275 publications

    77.9K citations

  6. National Institutes of Health

    Bethesda, United States

    52 h-index

    310 publications

    31.4K citations

  7. Johns Hopkins University

    Baltimore, United States

    51 h-index

    261 publications

    57K citations

  8. Centre National de la Recherche Scientifique

    Paris, France

    50 h-index

    347 publications

    30.3K citations

1–8 of 3.8K

Venues

  1. Journal of Biological Chemistry

    JBC · 312 publications · 40.9K citations

    110

    h-index

  2. Proceedings of the National Academy of Sciences

    PNAS · 113 publications · 28.3K citations

    91

    h-index

  3. Molecular and Cellular Biology

    MCB · 123 publications · 18.2K citations

    79

    h-index

  4. Journal of Medicinal Chemistry

    112 publications · 9.1K citations

    61

    h-index

  5. PLoS ONE

    129 publications · 6.8K citations

    50

    h-index

1–5