Manfred Jung

Histone deacetylase (HDAC) inhibitors in recent clinical trials for cancer therapy

Julia M. Wagner, Björn Hackanson, Michael Lübbert et al. · Clinical Epigenetics · 2010 · 394 citations · Full text

Histone Modifications, Chromatin, Cancer Therapy +9

SIRT1 Regulates HIV Transcription via Tat Deacetylation

Sara Pagans, Angelika Pedal, Brian J. North et al. · PLoS Biology · 2005 · 327 citations · Full text

Transcriptional Regulation, Human Immunodeficiency Virus, Human Retrovirus +12

Selective Sirt2 inhibition by ligand-induced rearrangement of the active site

Tobias Rumpf, Matthias Schiedel, Berin Karaman et al. · Nature Communications · 2015 · 290 citations · Full text

Chemically Induced Degradation of Sirtuin 2 (Sirt2) by a Proteolysis Targeting Chimera (PROTAC) Based on Sirtuin Rearranging Ligands (SirReals)

Matthias Schiedel, Daniel Herp, Sören Hammelmann et al. · Journal of Medicinal Chemistry · 2017 · 261 citations · Full text

Medicinal Chemistry, Biochemistry, Induced Degradation +15

Structure–Activity Studies on Suramin Analogues as Inhibitors of NAD⁺‐Dependent Histone Deacetylases (Sirtuins)

Johannes Trapp, René Meier, Darunee Hongwiset et al. · ChemMedChem · 2007 · 191 citations

Suramin Analogues, Aldo-keto Reductase, Molecular Biology +18