Selective Sirt2 inhibition by ligand-induced rearrangement of the active site

Tobias Rumpf, Matthias Schiedel, Berin Karaman, +15

Nature Communications

Efficient, high accuracy ADER-WENO schemes for hydrodynamics and divergence-free magnetohydrodynamics

Dinshaw S. Balsara, Tobias Rumpf, Michael Dumbser, +1

Journal of Computational Physics

Numerical AnalysisEngineeringPhysicsFluid MechanicsHydrodynamics +6

Aminothiazoles as Potent and Selective Sirt2 Inhibitors: A Structure–Activity Relationship Study

Matthias Schiedel, Tobias Rumpf, Berin Karaman, +7

Journal of Medicinal Chemistry

Structure‐Based Development of an Affinity Probe for Sirtuin 2

Matthias Schiedel, Tobias Rumpf, Berin Karaman, +6

Angewandte Chemie International Edition

Molecular Basis for the Antiparasitic Activity of a Mercaptoacetamide Derivative That Inhibits Histone Deacetylase 8 (HDAC8) from the Human Pathogen Schistosoma mansoni

Diana A. Stolfa, Martin Marek, Julien Lancelot, +11

Journal of Molecular Biology

Crystal StructureAntiparasitic AgentMolecular BiologyMercaptoacetamide DerivativeChemical Biology +16

Novel 3-Arylideneindolin-2-ones as Inhibitors of NAD⁺-Dependent Histone Deacetylases (Sirtuins)

K. Huber, Jörg Schemies, Urszula Uciechowska, +7

Journal of Medicinal Chemistry

Cell CultureNovel 3-Arylideneindolin-2-onesChemical BiologyPharmaceutical ChemistryMolecular Pharmacology +14

Inhibitors of the NAD⁺-Dependent Protein Desuccinylase and Demalonylase Sirt5

Benjamin Maurer, Tobias Rumpf, Michael Scharfe, +6

ACS Medicinal Chemistry Letters

Histone ModificationsHistone DeacetylasesEpigenetic ChangeMolecular BiologyChemical Biology +18

Chromo-pharmacophores: photochromic diarylmaleimide inhibitors for sirtuins

Carolin Falenczyk, Matthias Schiedel, Berin Karaman, +6

Chemical Science

Medicinal ChemistryPharmaceutical ScienceProtein FunctionMolecular PathwayPhotochromic Diarylmaleimide Inhibitors +12

Seeding for sirtuins: microseed matrix seeding to obtain crystals of human Sirt3 and Sirt2 suitable for soaking

Tobias Rumpf, S. Gerhardt, Oliver Einsle, +1

Acta Crystallographica Section F Structural Biology Communications

Indole MoleculesEngineeringBiochemistryNatural SciencesHuman Sirt3 +10

Lestaurtinib Inhibits Histone Phosphorylation and Androgen-Dependent Gene Expression in Prostate Cancer Cells

Jens Köhler, German Erlenkamp, Adrien Eberlin, +6

PLoS ONE