Concepedia

Small-molecule Activators

Small-Molecule Activators is a class of enzyme activators consisting of low molecular weight compounds that enhance enzymatic activity by directly binding to the enzyme or an associated regulatory protein, thereby distinguishing them from macromolecular or genetic activators.

254

Publications

26.7K

Citations

2.3K

Authors

556

Institutions

Publications per year

2017–2026

102

Parents

Publications

254

Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan

Konrad T. Howitz, Kevin J. Bitterman, Haim Cohen et al. · Nature · 2003 · 3.8K citations

, , +12

Frustrated Lewis Pair Chemistry: Development and Perspectives

Douglas W. Stephan, Gerhard Erker · Angewandte Chemie International Edition · 2015 · 1.8K citations

, , +15

Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes

Jill C. Milne, Philip Lambert, Simon Schenk et al. · Nature · 2007 · 1.7K citations · Full text

, , +14

Identification and characterization of a small molecule AMPK activator that treats key components of type 2 diabetes and the metabolic syndrome

Barbara L. Cool, Bradley A. Zinker, William J. Chiou et al. · Cell Metabolism · 2006 · 918 citations · Full text

, , +14

SRT1720, SRT2183, SRT1460, and Resveratrol Are Not Direct Activators of SIRT1

Michelle Pacholec, John E. Bleasdale, Boris A. Chrunyk et al. · Journal of Biological Chemistry · 2010 · 896 citations · Full text

, , +13

1–5 of 254

Authors

2.3K

  1. LO
    Liang Ouyang

    Sichuan University, China

    5 publications · 284 citations

    5

    h-index

  2. BB
    Bei B. Zhang

    Merck & Co., Inc., Rahway, NJ, USA (United States), United States

    4 publications · 198 citations

    4

    h-index

  3. LZ
    Lan Zhang

    Fudan University, China

    4 publications · 262 citations

    4

    h-index

  4. SI
    Sudeh Izadmehr

    Icahn School of Medicine at Mount Sinai, United States

    4 publications · 354 citations

    4

    h-index

  5. SL
    Siva Lavu

    Harvard University, United States

    4 publications · 5.8K citations

    4

    h-index

1–5 of 2.3K

Institutions

556

  1. University of California, San Francisco

    San Francisco, United States

    12 h-index

    64 publications

    5.7K citations

  2. Harvard University

    Cambridge, United States

    9 h-index

    30 publications

    26.1K citations

  3. GlaxoSmithKline (United Kingdom)

    London, United Kingdom

    9 h-index

    48 publications

    2K citations

  4. Scripps Research Institute

    San Diego, United States

    8 h-index

    48 publications

    6.7K citations

  5. Stanford University

    Stanford, United States

    8 h-index

    41 publications

    6.3K citations

  6. GlaxoSmithKline (United States)

    Philadelphia, United States

    7 h-index

    36 publications

    3.1K citations

  7. Sichuan University

    Chengdu, China

    7 h-index

    55 publications

    3.1K citations

  8. Pfizer (United States)

    New York, United States

    7 h-index

    167 publications

    26.8K citations

1–8 of 556

Venues

  1. Journal of Medicinal Chemistry

    20 publications · 1K citations

    19

    h-index

  2. Proceedings of the National Academy of Sciences

    PNAS · 13 publications · 1.3K citations

    13

    h-index

  3. PLoS ONE

    13 publications · 994 citations

    12

    h-index

  4. Journal of Biological Chemistry

    JBC · 8 publications · 1.7K citations

    8

    h-index

  5. Nature Communications

    8 publications · 1.5K citations

    8

    h-index

1–5