William J. Chiou

Identification and characterization of a small molecule AMPK activator that treats key components of type 2 diabetes and the metabolic syndrome

Barbara L. Cool, Bradley A. Zinker, William J. Chiou et al. · Cell Metabolism · 2006 · 904 citations · Full text

Metabolic Syndrome, Signal Transduction, Biochemistry +12

Pharmacological characterization of A-127722: an orally active and highly potent ETA-selective receptor antagonist.

Terry J. Opgenorth, Andrew Adler, Samuel V. Calzadilla et al. · Journal of Pharmacology and Experimental Therapeutics · 1996 · 209 citations

2,4-Diarylpyrrolidine-3-carboxylic AcidsPotent ET_A Selective Endothelin Receptor Antagonists. 1. Discovery of A-127722

Martin Winn, Thomas W von Geldern, Terry J. Opgenorth et al. · Journal of Medicinal Chemistry · 1996 · 110 citations · Full text

Combinatorial Chemistry, Molecular Pharmacology, Medicinal Chemistry +12

Simultaneous quantification of malonyl-CoA and several other short-chain acyl-CoAs in animal tissues by ion-pairing reversed-phase HPLC/MS

Lan Gao, William J. Chiou, Hua Tang et al. · Journal of Chromatography B · 2007 · 101 citations

Biochemistry, Medicine, Bioanalysis +10

Pyrrolidine-3-carboxylic Acids as Endothelin Antagonists. 4. Side Chain Conformational Restriction Leads to ET_B Selectivity

Thomas W von Geldern, Andrew S. Tasker, Bryan K. Sorensen et al. · Journal of Medicinal Chemistry · 1999 · 90 citations · Full text

Hypertension, Pharmacotherapy, Chemical Biology +16