Pharmacological characterization of A-127722: an orally active and highly potent ETA-selective receptor antagonist.

Terry J. Opgenorth, Andrew Adler, Samuel V. Calzadilla, +12

Journal of Pharmacology and Experimental Therapeutics

2,4-Diarylpyrrolidine-3-carboxylic AcidsPotent ET_A Selective Endothelin Receptor Antagonists. 1. Discovery of A-127722

Martin Winn, Thomas W von Geldern, Terry J. Opgenorth, +13

Journal of Medicinal Chemistry

Combinatorial ChemistryMolecular PharmacologyMedicinal ChemistryBiochemistryMedicine +10

Pyrrolidine-3-carboxylic Acids as Endothelin Antagonists. 4. Side Chain Conformational Restriction Leads to ET_B Selectivity

Thomas W von Geldern, Andrew S. Tasker, Bryan K. Sorensen, +10

Journal of Medicinal Chemistry

HypertensionPharmacotherapyChemical BiologyPharmaceutical ChemistryBlood Pressure +14

Adamantane sulfone and sulfonamide 11-β-HSD1 Inhibitors

Bryan K. Sorensen, Martin Winn, Jeff Rohde, +18

Bioorganic & Medicinal Chemistry Letters

Molecular PharmacologyMedicinal ChemistryAdamantane SulfoneBiochemistryMedicine +6

Pharmacology of endothelin receptor antagonists ABT-627, ABT-546, A-182086 and A-192621: <i>ex vivo</i> and <i>in vivo</i> studies

Jerry L. Wessale, Andrew Adler, Eugene I. Novosad, +8

Clinical Science

Discovery of Novel <i>p</i>-Arylthio Cinnamides as Antagonists of Leukocyte Function-Associated Antigen-1/Intercellular Adhesion Molecule-1 Interaction. 4. Structure−Activity Relationship of Substituents on the Benzene Ring of the Cinnamide

Martin Winn, Edward B. Reilly, Gang Liu, +13

Journal of Medicinal Chemistry

Pharmaceutical ScienceImmunologyP-arylthio CinnamidesChemical BiologyPharmaceutical Chemistry +18

Conformationally defined adrenergic agents. 1. Design and synthesis of novel .alpha.2-selective adrenergic agents: electrostatic repulsion based conformational prototypes

John F. DeBernardis, Daniel J. Kerkman, Martin Winn, +5

Journal of Medicinal Chemistry

Combinatorial ChemistryAdrenergic AgentsElectrostatic Repulsion HypothesisOrganic ChemistryPeptide Science +16

Pharmacology of endothelin receptor antagonists ABT-627, ABT-546, A-182086 and A-192621: <i>in vitro</i> studies

Jinshyun R. Wu‐Wong, Douglas B. Dixon, William J. Chiou, +7

Clinical Science

ImmunologyExperimental Pharmacology21-Amino-acid PeptidesMolecular PharmacologyMedicinal Chemistry +17

Intramolecular amidoalkylations at carbon. Synthesis of heterocyclic amines

Martin Winn, Harold E. Zaugg

The Journal of Organic Chemistry

HeterocyclicDonut IconAltmetric Attention ScoreChemometricsOrganic Chemistry +7

Potent and Selective Non-Benzodioxole-Containing Endothelin-A Receptor Antagonists

Andrew S. Tasker, Bryan K. Sorensen, Hwan-Soo Jae, +10

Journal of Medicinal Chemistry

Molecular PharmacologyMedicinal ChemistryBiochemistryReceptor Subtype SelectivityMedicine +12