Adamantane sulfone and sulfonamide 11-β-HSD1 Inhibitors

A Transgenic Model of Visceral Obesity and the Metabolic Syndrome

Hiroaki Masuzaki, J. Paterson, Hiroshi Shinyama et al. · Science · 2001 · 1.8K citations

Medicine, Biochemistry, Endocrinology +17

11β-Hydroxysteroid dehydrogenase type 1 knockout mice show attenuated glucocorticoid-inducible responses and resist hyperglycemia on obesity or stress

Yuri Kotelevtsev, Megan C. Holmes, Ann N. Burchell et al. · Proceedings of the National Academy of Sciences · 1997 · 855 citations

Life Sciences, Biochemistry, Endocrinology +17

Novel Adipose Tissue–Mediated Resistance to Diet-Induced Visceral Obesity in 11β-Hydroxysteroid Dehydrogenase Type 1–Deficient Mice

Nicholas M. Morton, Janice M. Paterson, Hiroaki Masuzaki et al. · Diabetes · 2004 · 504 citations · Full text

Medicine, Endocrinology, Physiology +17

Improved Lipid and Lipoprotein Profile, Hepatic Insulin Sensitivity, and Glucose Tolerance in 11β-Hydroxysteroid Dehydrogenase Type 1 Null Mice

Nicholas M. Morton, Megan C. Holmes, Catherine Fiévet et al. · Journal of Biological Chemistry · 2001 · 437 citations · Full text

Life Sciences, Biochemistry, Endocrinology +17

Transgenic amplification of glucocorticoid action in adipose tissue causes high blood pressure in mice

Hiroaki Masuzaki, Hiroshi Yamamoto, Christopher J. Kenyon et al. · Journal of Clinical Investigation · 2003 · 428 citations · Full text

Life Sciences, Endocrinology, Physiology +17