Pyrrolidine-5,5-trans-lactams as novel mechanism-based inhibitors of human cytomegalovirus protease. Part 3: potency and plasma stability

Design and synthesis of monocyclic β-lactams as mechanism-based inhibitors of human cytomegalovirus protease

Alan D. Borthwick, Gordon G. Weingarten, Terry Haley et al. · Bioorganic & Medicinal Chemistry Letters · 1998 · 168 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +12

Design and Synthesis of Pyrrolidine-5,5-<i>trans-</i>lactams (5-Oxohexahydropyrrolo[3,2-<i>b</i>]pyrroles) as Novel Mechanism-Based Inhibitors of Human Cytomegalovirus Protease. 2. Potency and Chirality

Alan D. Borthwick, Andrew J. Crame, Peter Ertl et al. · Journal of Medicinal Chemistry · 2001 · 72 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +16

Peptidyl .alpha.-ketoheterocyclic inhibitors of human neutrophil elastase. 2. Effect of varying the heterocyclic ring on in vitro potency

Philip D. Edwards, Donald J. Wolanin, Donald W. Andisik et al. · Journal of Medicinal Chemistry · 1995 · 69 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +8

Orally active .beta.-lactam inhibitors of human leukocyte elastase-1. Activity of 3,3-diethyl-2-azetidinones

S. K. Shah, Conrad P. Dorn, P E Finke et al. · Journal of Medicinal Chemistry · 1992 · 68 citations

Medicine, Medicinal Chemistry, Pharmacology +5

Synthesis and Structure-Activity Relationships of Peptidyl .alpha.-Keto Heterocycles as Novel Inhibitors of Prolyl Endopeptidase

Seiji Tsutsumi, Tsuneo Okonogi, Seiji Shibahara et al. · Journal of Medicinal Chemistry · 1994 · 63 citations · Full text

Pharmacy, Chemistry, Medicinal Chemistry +17