Design and synthesis of monocyclic β-lactams as mechanism-based inhibitors of human cytomegalovirus protease

A new serine-protease fold revealed by the crystal structure of human cytomegalovirus protease

Liang Tong, Chungeng Qian, Marie-Josée Massariol et al. · Nature · 1996 · 157 citations

Virus Structure, Crystal Structure, Biochemistry +11

Azetidin-2-one derivatives as inhibitors of thrombin

William T. Han, Ashok K. Trehan, J. J. Wright et al. · Bioorganic & Medicinal Chemistry · 1995 · 155 citations

Thrombosis, Medicinal Chemistry, Azetidin-2-one Derivatives +10

Structure of the Human Cytomegalovirus Protease Catalytic Domain Reveals a Novel Serine Protease Fold and Catalytic Triad

Ping Chen, Hideaki Tsuge, Robert J. Almassy et al. · Cell · 1996 · 150 citations · Full text

Virus Structure, Biochemistry, Protein Folding +7

Unique fold and active site in cytomegalovirus protease

Xiayang Qiu, Jeffrey S. Culp, Anthony G. DiLella et al. · Nature · 1996 · 148 citations

Virus Structure, Viral Replication, Protein Folding +8

Three-dimensional structure of human cytomegalovirus protease

Huey‐Sheng Shieh, Ravi G. Kurumbail, Anna M. Stevens et al. · Nature · 1996 · 148 citations

Virus Structure, Viral Replication, Protein Folding +6