Alan D. Borthwick - Concepedia

Author

Alan D. Borthwick

Also Known As

A. D. BORTHWICK, A. D. Borthwick, A.D. Borthwick, ALAN D. BORTHWICK, Alan Borthwick, Alan D Borthwick, Alan D. Borthwick, Alan D. Borthwick, Borthwick, A.D., Jennifer A. Borthwick

Publications

3.1K

Citations

H-Index

Concepts

All Affiliations

GlaxoSmithKline (United Kingdom)GlaxoSmithKline (United States)Age UK GlaxoSmithKline (Germany)

About

Alan D. Borthwick is an author at GlaxoSmithKline (United Kingdom) specializing in natural sciences, pharmacology, and drug discovery.

Top Concepts

#	Concept	H-Index	Publications	Citations
1	Natural Sciences	21	26	1K
2	Medicine	19	20	953
3	Biochemistry	19	21	876
4	Engineering	9	9	256
5	Biology	1	1	38

Alan D. Borthwick

Publications

Citations

H-Index

Page 1

	Year	Citations
Synthesis of chiral carbocyclic nucleosides Alan D. Borthwick, Keith Biggadike Tetrahedron Organic ChemistryChiral Carbocyclic NucleosidesStereoselective SynthesisChemistryAsymmetric Catalysis	1992	351
Design and synthesis of monocyclic β-lactams as mechanism-based inhibitors of human cytomegalovirus protease Alan D. Borthwick, Gordon Weingarten, Terry Haley, Bioorganic & Medicinal Chemistry Letters Mechanism-based InhibitorsMedicineDrug DiscoveryAntiviral Drug DevelopmentAntiviral Therapy	1998	167
The discovery of GSK221149A: A potent and selective oxytocin antagonist John Liddle, Michael Allen, Alan D. Borthwick, Bioorganic & Medicinal Chemistry Letters Selective OxytocinMedicinal ChemistryBiochemistryG Protein-coupled ReceptorMedicine	2007	90
Pyridyl-2,5-Diketopiperazines as Potent, Selective, and Orally Bioavailable Oxytocin Antagonists: Synthesis, Pharmacokinetics, and In Vivo Potency Alan D. Borthwick, John Liddle, Dave E. Davies, Journal of Medicinal Chemistry	2012	89
Design and Synthesis of Pyrrolidine-5,5-<i>trans-</i>lactams (5-Oxohexahydropyrrolo[3,2-<i>b</i>]pyrroles) as Novel Mechanism-Based Inhibitors of Human Cytomegalovirus Protease. 2. Potency and Chirality Alan D. Borthwick, Andrew J. Crame, Peter Ertl, Journal of Medicinal Chemistry Hcmv Deltaala ProteaseBioorganic ChemistryNovel Mechanism-based InhibitorsAntiviral DrugChemical Biology	2001	72
Design and Synthesis of Pyrrolidine-5,5‘-<i>trans-</i>Lactams (5-Oxo-hexahydropyrrolo[3,2-<i>b</i>]pyrroles) as Novel Mechanism-Based Inhibitors of Human Cytomegalovirus Protease. 4. Antiviral Activity and Plasma Stability Alan D. Borthwick, Dave E. Davies, Peter Ertl, Journal of Medicinal Chemistry	2003	71
2,5-Diketopiperazines as potent and selective oxytocin antagonists 1: identification, stereochemistry and initial SAR Paul G. Wyatt, Michael Allen, Alan D. Borthwick, Bioorganic & Medicinal Chemistry Letters Selective OxytocinMedicinal ChemistryDrug TargetBiochemistryInitial Sar	2005	66
Synthesis and enzymatic resolution of carbocyclic 2′-ara-fluoro-guanosine: a potent new anti-herpetic agent Alan D. Borthwick, Suzanne Butt, Keith Biggadike, Journal of the Chemical Society Chemical Communications Bioorganic ChemistrySynthetic VirologyAntiviral DrugPharmaceutical ChemistryCorresponding Furanose Compound	1988	58
Fluoro carbocyclic nucleosides: synthesis and antiviral activity of 2'- and 6'-fluoro carbocyclic pyrimidine nucleosides including carbocyclic 1-(2-deoxy-2-fluoro-.beta.-D-arabinofuranosyl)-5-methyluracil and carbocyclic 1-(2-deoxy-2-fluoro-.beta.-D-arabinofuranosyl)-5-iodouracil Alan D. Borthwick, Derek N. Evans, Barrie E. Kirk, Journal of Medicinal Chemistry Medicinal ChemistryPharmaceutical ChemistryBioorganic ChemistryKetone 23Biochemistry	1990	57
2,5-Diketopiperazines as Potent, Selective, and Orally Bioavailable Oxytocin Antagonists. 2. Synthesis, Chirality, and Pharmacokinetics Alan D. Borthwick, Dave E. Davies, Anne M. Exall, Journal of Medicinal Chemistry Molecular PharmacologyMedicinal ChemistryShort Stereoselective SynthesisPharmaceutical SciencePharmacological Study	2005	53

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