Alan D. Borthwick

Synthesis of chiral carbocyclic nucleosides

Alan D. Borthwick, Keith Biggadike · Tetrahedron · 1992 · 351 citations

Organic Chemistry, Chiral Carbocyclic Nucleosides, Stereoselective Synthesis +3

Design and synthesis of monocyclic β-lactams as mechanism-based inhibitors of human cytomegalovirus protease

Alan D. Borthwick, Gordon Weingarten, Terry Haley et al. · Bioorganic & Medicinal Chemistry Letters · 1998 · 167 citations · Full text

Mechanism-based Inhibitors, Medicine, Drug Discovery +8

The discovery of GSK221149A: A potent and selective oxytocin antagonist

John Liddle, Michael Allen, Alan D. Borthwick et al. · Bioorganic & Medicinal Chemistry Letters · 2007 · 90 citations · Full text

Selective Oxytocin, Medicinal Chemistry, Biochemistry +9

Pyridyl-2,5-Diketopiperazines as Potent, Selective, and Orally Bioavailable Oxytocin Antagonists: Synthesis, Pharmacokinetics, and In Vivo Potency

Alan D. Borthwick, John Liddle, Dave E. Davies et al. · Journal of Medicinal Chemistry · 2012 · 89 citations · Full text

Design and Synthesis of Pyrrolidine-5,5-<i>trans-</i>lactams (5-Oxohexahydropyrrolo[3,2-<i>b</i>]pyrroles) as Novel Mechanism-Based Inhibitors of Human Cytomegalovirus Protease. 2. Potency and Chirality

Alan D. Borthwick, Andrew J. Crame, Peter Ertl et al. · Journal of Medicinal Chemistry · 2001 · 72 citations · Full text

Hcmv Deltaala Protease, Bioorganic Chemistry, Novel Mechanism-based Inhibitors +17