Keith Biggadike

Synthesis of chiral carbocyclic nucleosides

Alan D. Borthwick, Keith Biggadike · Tetrahedron · 1992 · 351 citations

Organic Chemistry, Chiral Carbocyclic Nucleosides, Stereoselective Synthesis +3

Selective Plasma Hydrolysis of Glucocorticoid γ-Lactones and Cyclic Carbonates by the Enzyme Paraoxonase: An Ideal Plasma Inactivation Mechanism

Keith Biggadike, Richard Angell, Colin M. Burgess et al. · Journal of Medicinal Chemistry · 1999 · 180 citations · Full text

Medicinal Chemistry, Biochemistry, Medicine +13

Pharmacological properties of the enhanced-affinity glucocorticoid fluticasone furoate in vitro and in an in vivo model of respiratory inflammatory disease

Mark Salter, Keith Biggadike, Joyce Matthews et al. · American Journal of Physiology-Lung Cellular and Molecular Physiology · 2007 · 143 citations

Asthma, Inflammatory Lung Disease, Lung Inflammation +19

X-ray Crystal Structure of the Novel Enhanced-Affinity Glucocorticoid Agonist Fluticasone Furoate in the Glucocorticoid Receptor−Ligand Binding Domain

Keith Biggadike, Randy K. Bledsoe, Anne M. Hassell et al. · Journal of Medicinal Chemistry · 2008 · 112 citations

Molecular Pharmacology, Medicinal Chemistry, Biochemistry +12

Synthesis and Structure−Activity Relationships of Long-acting β₂Adrenergic Receptor Agonists Incorporating Metabolic Inactivation: An Antedrug Approach

Panayiotis A. Procopiou, Victoria J. Barrett, Nicola Bevan et al. · Journal of Medicinal Chemistry · 2010 · 98 citations · Full text