Keith Biggadike

Synthesis of chiral carbocyclic nucleosides

Alan D. Borthwick, Keith Biggadike · Tetrahedron · 1992 · 351 citations

Pharmacy, Chemistry, Medicinal Chemistry +12

Selective Plasma Hydrolysis of Glucocorticoid γ-Lactones and Cyclic Carbonates by the Enzyme Paraoxonase: An Ideal Plasma Inactivation Mechanism

Keith Biggadike, Richard Angell, Colin M. Burgess et al. · Journal of Medicinal Chemistry · 1999 · 180 citations · Full text

Life Sciences, Medicinal Chemistry, Pharmacology +10

Pharmacological properties of the enhanced-affinity glucocorticoid fluticasone furoate in vitro and in an in vivo model of respiratory inflammatory disease

Mark Salter, Keith Biggadike, Joyce Matthews et al. · American Journal of Physiology-Lung Cellular and Molecular Physiology · 2007 · 145 citations

Life Sciences, Pharmacology, Pharmacotherapy +17

X-ray Crystal Structure of the Novel Enhanced-Affinity Glucocorticoid Agonist Fluticasone Furoate in the Glucocorticoid Receptor−Ligand Binding Domain

Keith Biggadike, Randy K. Bledsoe, Anne M. Hassell et al. · Journal of Medicinal Chemistry · 2008 · 112 citations

Medicine, Medicinal Chemistry, Pharmacology +16

Synthesis and Structure−Activity Relationships of Long-acting β₂Adrenergic Receptor Agonists Incorporating Metabolic Inactivation: An Antedrug Approach

Panayiotis A. Procopiou, Victoria J. Barrett, Nicola Bevan et al. · Journal of Medicinal Chemistry · 2010 · 99 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +16