Andrew J. Crame

Design and Synthesis of Pyrrolidine-5,5-<i>trans-</i>lactams (5-Oxohexahydropyrrolo[3,2-<i>b</i>]pyrroles) as Novel Mechanism-Based Inhibitors of Human Cytomegalovirus Protease. 2. Potency and Chirality

Alan D. Borthwick, Andrew J. Crame, Peter Ertl et al. · Journal of Medicinal Chemistry · 2001 · 72 citations · Full text

Hcmv Deltaala Protease, Bioorganic Chemistry, Novel Mechanism-based Inhibitors +17

Design and Synthesis of Pyrrolidine-5,5-<i>trans-</i>lactams (5-Oxo-hexahydro-pyrrolo[3,2-<i>b</i>]pyrroles) as Novel Mechanism-Based Inhibitors of Human Cytomegalovirus Protease. 1. The α-Methyl-<i>trans</i>-lactam Template

Alan D. Borthwick, S. Jane Angier, Andrew J. Crame et al. · Journal of Medicinal Chemistry · 2000 · 46 citations · Full text

An efficient synthesis of a chiral carbocyclic 2′-deoxyribonucleoside synthon by directed reduction

Alan D. Borthwick, Andrew J. Crame, Anne M. Exall et al. · Tetrahedron Letters · 1994 · 16 citations

Bioorganic Chemistry, Engineering, Natural Sciences +11

A short, convergent synthesis of two chiral antiviral agents, (+) carbocyclic 2′-deoxy-5-[(E)-2-bromovinyl] uridine and (+) carbocyclic 2′-deoxyGuanosine

Alan D. Borthwick, Andrew J. Crame, Anne M. Exall et al. · Tetrahedron Letters · 1995 · 13 citations

Engineering, Antiviral Drug Development, Antiviral Therapy +8