Chemical Communications · 2011 · 37 citations · 16 references
PharmacyMedicinal ChemistryPharmacologyCancer PharmacologyComputational Medicinal ChemistryDrug DiscoveryHedgehog SignalingCanonical Hedgehog SignalingHedgehog Pathway InhibitorsHedgehog Signaling InhibitionOrganic Molecule SynthesisPharmacological Targeting Of Hedgehog SignalingSignal Transduction In Hedgehog PathwayVertebrate Hedgehog Signaling
The combination of theoretical and computational studies with organic synthesis and biological investigations has led to exo-cyclopamine. This stable and highly potent derivative of cyclopamine promises big potential as an experimental drug against several types of human cancer.
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Effects of oncogenic mutations in Smoothened and Patched can be reversed by cyclopamine
Jussi Taipale, James Chen, Michael K. Cooper et al. · Nature · 2000 · 1.3K citations
A paracrine requirement for hedgehog signalling in cancer
Robert L. Yauch, Stephen E. Gould, Suzie J. Scales et al. · Nature · 2008 · 955 citations
Medicine, Cancer Biology, Oncology +14
Hedgehog signalling is essential for maintenance of cancer stem cells in myeloid leukaemia
Chen Zhao, Alan Chen, Catriona Jamieson et al. · Nature · 2009 · 861 citations · Full text
Medicine, Cancer Biology, Oncology +16
Teratogen-Mediated Inhibition of Target Tissue Response to <i>Shh</i> Signaling
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