Conjugation site modulates the in vivo stability and therapeutic activity of antibody-drug conjugates

Ben‐Quan Shen, Keyang Xu, Luna Liu, +30

Nature Biotechnology

ImmunoengineeringImmunologyBioconjugationAntibody EngineeringImmunotherapeutics +6

A paracrine requirement for hedgehog signalling in cancer

Robert L. Yauch, Stephen E. Gould, Suzie J. Scales, +12

Nature

Cancer ResearchSignaling PathwayMedicineParacrine RequirementTumor Suppressor +4

Mapping the NPHP-JBTS-MKS Protein Network Reveals Ciliopathy Disease Genes and Pathways

Liyun Sang, Julie J. Miller, Kevin C. Corbit, +29

Cell

Molecular NeuroscienceDisease MechanismGliomaMolecular BiologyComplex Disease +5

CRIg: A Macrophage Complement Receptor Required for Phagocytosis of Circulating Pathogens

Karim Y. Helmy, Kenneth J. Katschke, Nick N. Gorgani, +6

Cell

InflammationHost ResponseComplement SystemMicrobial PathogensPathogenesis +5

Visualization of ER-to-Golgi Transport in Living Cells Reveals a Sequential Mode of Action for COPII and COPI

Suzie J. Scales, Rainer Pepperkok, Thomas E. Kreis

Cell

Golgi ApparatusSignal TransductionOrganelle DynamicMedicineCell Trafficking +11

The Ciliary G-Protein-Coupled Receptor Gpr161 Negatively Regulates the Sonic Hedgehog Pathway via cAMP Signaling

Saikat Mukhopadhyay, Xiaohui Wen, Navneet Ratti, +4

Cell

Signal TransductionDevelopmental BiologySignaling PathwayG Protein-coupled ReceptorCell Interaction +6

TULP3 bridges the IFT-A complex and membrane phosphoinositides to promote trafficking of G protein-coupled receptors into primary cilia

Saikat Mukhopadhyay, Xiaohui Wen, Ben Chih, +4

Genes & Development

Molecular BiologyIft-a ComplexSynaptic SignalingCellular PhysiologySignaling Pathway +18

SNARE Complex Formation Is Triggered by Ca 2+ and Drives Membrane Fusion

Yu A. Chen, Suzie J. Scales, Sejal M. Patel, +2

Cell

Membrane FusionSnare Complex FormationCa 2+Signal TransductionProtein Secretion +11

Hedgehog signaling is restricted to the stromal compartment during pancreatic carcinogenesis

Hua Tian, Christopher A. Callahan, Kelly DuPree, +4

Proceedings of the National Academy of Sciences

Cancer ResearchPancreatic CarcinogenesisHh PathwayDevelopmental BiologyHedgehog Signaling +13

Small Molecule Inhibition of GDC-0449 Refractory Smoothened Mutants and Downstream Mechanisms of Drug Resistance

Gerrit J.P. Dijkgraaf, Bruno Alicke, Lasse Weinmann, +11

Cancer Research

Molecular BiologyGliomaSmall Molecule InhibitionTumor BiologyDrug Resistance +16