Concepedia

Insulin Activation of Rheb, a Mediator of mTOR/S6K/4E-BP Signaling, Is Inhibited by TSC1 and 2

Attila Garami, Fried Zwartkruis, Takahiro Nobukuni, Manel Joaquin, Marta Roccio, Hugo Stocker, Sara C. Kozma, Ernst Hafen, Johannes L. Bos, George Thomas

Molecular Cell · 2003 · 1K citations · 42 references

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42

TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling

Ken Inoki, Yong Li, Tianquan Zhu et al. · Nature Cell Biology · 2002 · 3.1K citations

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mTOR Interacts with Raptor to Form a Nutrient-Sensitive Complex that Signals to the Cell Growth Machinery

Do‐Hyung Kim, Dos D. Sarbassov, Siraj M. Ali et al. · Cell · 2002 · 3K citations · Full text

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Germline mutations of the PTEN gene in Cowden disease, an inherited breast and thyroid cancer syndrome

Danny Liaw, Jing Li, Patricia L. M. Dahia et al. · Nature Genetics · 1997 · 2.1K citations

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Two TOR Complexes, Only One of which Is Rapamycin Sensitive, Have Distinct Roles in Cell Growth Control

Robbie Loewith, Estela Jacinto, Stephan Wullschleger et al. · Molecular Cell · 2002 · 1.9K citations · Full text

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Raptor, a Binding Partner of Target of Rapamycin (TOR), Mediates TOR Action

Kenta Hara, Yoshiko Maruki, K. Yoshino et al. · Cell · 2002 · 1.8K citations · Full text

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