Insulin Activation of Rheb, a Mediator of mTOR/S6K/4E-BP Signaling, Is Inhibited by TSC1 and 2

Attila Garami, Fried Zwartkruis, Takahiro Nobukuni, +7

Molecular Cell

Molecular PhysiologySignal TransductionInsulin ActivationSignaling PathwayReceptor Tyrosine Kinase +8

Amino acids mediate mTOR/raptor signaling through activation of class 3 phosphatidylinositol 3OH-kinase

Takahiro Nobukuni, Manel Joaquin, Marta Roccio, +9

Proceedings of the National Academy of Sciences

Class 3Amino AcidsMolecular RegulationMetabolic RemodelingInsulin Signaling +18

TSLC1 is a tumor-suppressor gene in human non-small-cell lung cancer

Masami Kuramochi, Hiroshi Fukuhara, Takahiro Nobukuni, +10

Nature Genetics

Tumor BiologyMedicineCancer GenomicsBronchial NeoplasmTumor Suppressor +7

Amino Acids Activate mTOR Complex 1 via Ca2+/CaM Signaling to hVps34

Pawan Gulati, Lawrence D. Gaspers, Stephen G. Dann, +6

Cell Metabolism

Protein FunctionSignal TransductionMolecular PhysiologyBiochemistryNatural Sciences +5

Tuberous sclerosis complex tumor suppressor–mediated S6 kinase inhibition by phosphatidylinositide-3-OH kinase is mTOR independent

Anja Jaeschke, Jörg Hartkamp, Masao Saitoh, +6

The Journal of Cell Biology

Identification of the prfC gene, which encodes peptide-chain-release factor 3 of Escherichia coli.

Osamu Mikuni, Keisuke Ito, J.B. Moffat, +5

Proceedings of the National Academy of Sciences

Protein ExpressionNatural SciencesGeneticsProtein BiosynthesisGene Structure +13

Effective <i>in vivo</i> targeting of the mammalian target of rapamycin pathway in malignant peripheral nerve sheath tumors

Gunnar Johansson, Yonatan Y. Mahller, Margaret H. Collins, +8

Molecular Cancer Therapeutics

Promoter Methylation of <i>TSLC1</i> and Tumor Suppression by Its Gene Product in Human Prostate Cancer

Hiroshi Fukuhara, Masami Kuramochi, Takeshi Fukami, +10

Japanese Journal of Cancer Research

Localization of tumor suppressor activity important in nonsmall cell lung carcinoma on chromosome 11q

Yoshinori Murakami, Takahiro Nobukuni, Kenji Tamura, +10

Proceedings of the National Academy of Sciences

Large-Scale Screening for Candidate Genes of Ossification of the Posterior Longitudinal Ligament of the Spine

Kozo Furushima, Kazuki Shimo‐Onoda, Shingo Maeda, +7

Journal of Bone and Mineral Research