George Thomas

Absence of S6K1 protects against age- and diet-induced obesity while enhancing insulin sensitivity

Sung Hee Um, Francesca Frigerio, Mitsuhiro Watanabe et al. · Nature · 2004 · 1.6K citations · Full text

Obesity, Metabolic Syndrome, Nutrition +11

Inhibition of mTORC1 leads to MAPK pathway activation through a PI3K-dependent feedback loop in human cancer

Arkaitz Carracedo, Li Ma, Julie Teruya‐Feldstein et al. · Journal of Clinical Investigation · 2008 · 1.4K citations · Full text

Hypothalamic mTOR Signaling Regulates Food Intake

Daniela Cota, Karine Proulx, Kathi A. Blake Smith et al. · Science · 2006 · 1.2K citations

Nutrition, Obesity, Nutrient Signalling +21

Ribosomal Protein S6 Kinase 1 Signaling Regulates Mammalian Life Span

Colin Selman, Jennifer M. A. Tullet, Daniela Wieser et al. · Science · 2009 · 1.1K citations

Anti-aging, Molecular Regulation, Cell Death +22

Insulin Activation of Rheb, a Mediator of mTOR/S6K/4E-BP Signaling, Is Inhibited by TSC1 and 2

Attila Garami, Fried Zwartkruis, Takahiro Nobukuni et al. · Molecular Cell · 2003 · 1K citations · Full text

Molecular Physiology, Signal Transduction, Insulin Activation +10