TSC2 Mediates Cellular Energy Response to Control Cell Growth and Survival

Ken Inoki, Tianqing Zhu, Kun‐Liang Guan

Cell

Signal TransductionControl Cell GrowthCell DivisionCell RegulationCell Control +8

TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling

Ken Inoki, Yong Li, Tianquan Zhu, +2

Nature Cell Biology

Signal TransductionSignaling PathwayCell RegulationSystems BiologyMedicine +3

Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)¹

Daniel J. Klionsky, Amal Kamal Abdel‐Aziz, Sara Abdelfatah, +1267

Autophagy

Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling

Ken Inoki, Yong Li, Tian Xu, +1

Genes & Development

TSC2 Integrates Wnt and Energy Signals via a Coordinated Phosphorylation by AMPK and GSK3 to Regulate Cell Growth

Ken Inoki, Hongjiao Ouyang, Tianqing Zhu, +13

Cell

Signal TransductionCell RegulationSignaling PathwayMedicineTsc2 Integrates Wnt +9

ATM signals to TSC2 in the cytoplasm to regulate mTORC1 in response to ROS

Angela Alexander, Sheng-Li Cai, Jinhee Kim, +10

Proceedings of the National Academy of Sciences

Essential function of TORC2 in PKC and Akt turn motif phosphorylation, maturation and signalling

Tsuneo Ikenoue, Ken Inoki, Qian Yang, +2

The EMBO Journal

Essential FunctionSignal TransductionMolecular PhysiologySignaling PathwayNatural Sciences +9

Spatial Coupling of mTOR and Autophagy Augments Secretory Phenotypes

Masako Narita, Andrew Young, Satoko Arakawa, +11

Science

MitophagyProtein SecretionImmunologyCytoskeletonCellular Physiology +15

Regulation of the TSC pathway by LKB1: evidence of a molecular link between tuberous sclerosis complex and Peutz-Jeghers syndrome

Michael N. Corradetti, Ken Inoki, Nabeel Bardeesy, +2

Genes & Development

Role of mTOR in podocyte function and diabetic nephropathy in humans and mice

Markus Gödel, Björn Hartleben, Nadja Herbach, +20

Journal of Clinical Investigation

ImmunologyPodocyte FunctionInflammationGlomerulonephritisMetabolic Syndrome +19