Nature Biotechnology · 2014 · 794 citations · 39 references
Life SciencesMolecular BiologyNeuroscienceGene FunctionGenome EditingMolecular NeuroscienceCrispr-based EngineeringCrispr-cas SystemsGene Expression In NeuronsGene Knockout StrategiesMolecular NeurogeneticsNeuronal Gene ExpressionCrispr-based Functional ScreeningCrispr-based Genome EngineeringCrispr-cas9 Genome EditingCrispr-cas9 Knockout ModelsCrispr-cas9 Validation
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A Programmable Dual-RNA–Guided DNA Endonuclease in Adaptive Bacterial Immunity
Martin Jínek, Krzysztof Chylinski, Ines Fonfara et al. · Science · 2012 · 17.3K citations · Full text
Multiplex Genome Engineering Using CRISPR/Cas Systems
Le Cong, F. Ann Ran, David Cox et al. · Science · 2013 · 15.7K citations
Genome engineering using the CRISPR-Cas9 system
F. Ann Ran, Patrick D. Hsu, Jason Wright et al. · Nature Protocols · 2013 · 11.7K citations · Full text
Repurposing CRISPR as an RNA-Guided Platform for Sequence-Specific Control of Gene Expression
Lei S. Qi, Matthew H. Larson, Luke A. Gilbert et al. · Cell · 2013 · 5.2K citations · Full text
DNA targeting specificity of RNA-guided Cas9 nucleases
Patrick D. Hsu, David A. Scott, Joshua A. Weinstein et al. · Nature Biotechnology · 2013 · 4.9K citations · Full text