Concepedia

Crispr-based Functional Screening

CRISPR-Based Functional Screening is a genome-wide functional genomics method that uses CRISPR-Cas nuclease systems to systematically perturb gene expression or function on a large scale, enabling the identification of genes associated with specific cellular phenotypes through targeted knockout or modulation.

293

Publications

41.5K

Citations

2.7K

Authors

623

Institutions

Publications per year

2017–2026

258

Variants

Crispr Functional Screening

Parents

Publications

293

Genome-Scale CRISPR-Cas9 Knockout Screening in Human Cells

Ophir Shalem, Neville E. Sanjana, Ella Hartenian et al. · Science · 2013 · 5.5K citations · Full text

, , +17

High-Resolution CRISPR Screens Reveal Fitness Genes and Genotype-Specific Cancer Liabilities

Traver Hart, Megha Chandrashekhar, Michael Aregger et al. · Cell · 2015 · 1.8K citations · Full text

, , +12

Prioritization of cancer therapeutic targets using CRISPR–Cas9 screens

Fiona M. Behan, Francesco Iorio, Gabriele Picco et al. · Nature · 2019 · 1.4K citations · Full text

, , +14

A Multiplexed Single-Cell CRISPR Screening Platform Enables Systematic Dissection of the Unfolded Protein Response

Britt Adamson, Thomas M. Norman, Marco Jost et al. · Cell · 2016 · 1.3K citations · Full text

, , +12

In vivo CRISPR screening identifies Ptpn2 as a cancer immunotherapy target

Robert T. Manguso, Hans W. Pope, Margaret D. Zimmer et al. · Nature · 2017 · 1.1K citations

, , +15

1–5 of 293

Authors

2.7K

  1. JG
    John G. Doench

    Broad Institute, United States

    12 publications · 8.7K citations

    12

    h-index

  2. DE
    David E. Root

    Broad Institute, United States

    11 publications · 9K citations

    11

    h-index

  3. MC
    Michael C. Bassik

    Stanford University, United States

    9 publications · 1.5K citations

    9

    h-index

  4. JS
    Jonathan S. Weissman

    Howard Hughes Medical Institute, United States

    9 publications · 5.4K citations

    9

    h-index

  5. TH
    Traver Hart

    The University of Texas MD Anderson Cancer Center, United States

    8 publications · 2.4K citations

    8

    h-index

1–5 of 2.7K

Institutions

623

  1. Harvard University

    Cambridge, United States

    30 h-index

    185 publications

    38.5K citations

  2. Broad Institute

    Cambridge, United States

    29 h-index

    253 publications

    113.7K citations

  3. Howard Hughes Medical Institute

    Chevy Chase, United States

    26 h-index

    93 publications

    45.3K citations

  4. University of California, San Francisco

    San Francisco, United States

    23 h-index

    147 publications

    73.1K citations

  5. Stanford University

    Stanford, United States

    22 h-index

    211 publications

    40.1K citations

  6. Dana-Farber Cancer Institute

    Boston, United States

    17 h-index

    96 publications

    23.2K citations

  7. Massachusetts Institute of Technology

    Cambridge, United States

    15 h-index

    58 publications

    45.3K citations

  8. Yale University

    New Haven, United States

    14 h-index

    100 publications

    17.8K citations

1–8 of 623

Venues

  1. Nature Communications

    17 publications · 2.4K citations

    15

    h-index

  2. bioRxiv (Cold Spring Harbor Laboratory)

    Repository · 13 publications · 672 citations

    11

    h-index

  3. Cell

    11 publications · 6.6K citations

    11

    h-index

  4. Nature

    10 publications · 4.9K citations

    10

    h-index

  5. Science

    9 publications · 7.9K citations

    9

    h-index

1–5