A Multiplexed Single-Cell CRISPR Screening Platform Enables Systematic Dissection of the Unfolded Protein Response

Britt Adamson, Thomas M. Norman, Marco Jost, +14

Cell

Genome SurgerySingle Cell SequencingMedicineUnfolded Protein ResponseMolecular Biology +6

Mapping information-rich genotype-phenotype landscapes with genome-scale Perturb-seq

Joseph M. Replogle, Reuben A. Saunders, Angela N. Pogson, +14

Cell

Molecular recording of mammalian embryogenesis

Michelle M. Chan, Zachary D. Smith, Stefanie Grosswendt, +11

Nature

Embryonic Stem CellDevelopmental BiologyMorphogenesisEmbryonic DevelopmentMolecular Recording +3

Exploring genetic interaction manifolds constructed from rich single-cell phenotypes

Thomas M. Norman, Max A. Horlbeck, Joseph M. Replogle, +5

Science

Combined CRISPRi/a-Based Chemical Genetic Screens Reveal that Rigosertib Is a Microtubule-Destabilizing Agent

Marco Jost, Yuwen Chen, Luke A. Gilbert, +12

Molecular Cell

EngineeringBiotechnologySynthetic BiologyGenetic EngineeringMolecular Biology +6

Structural basis for gene regulation by a B12-dependent photoreceptor

Marco Jost, Jesús Fernández‐Zapata, María Carmen Polanco, +6

Nature

Photoreceptor CellSignal TransductionMolecular RegulationMolecular BiologyStructural Basis +1

Microfluidics-free single-cell genomics with templated emulsification

Iain C. Clark, Kristina M. Fontanez, Robert H. Meltzer, +22

Nature Biotechnology

EngineeringImmunologyBiofabricationMultiomicsNew Applications +25

Arteriogenesis depends on circulating monocytes and macrophage accumulation and is severely depressed in op/op mice

Caroline Bergmann, Imo E. Hoefer, Benjamin Meder, +7

Journal of Leukocyte Biology

Arteriogenesis Proceeds via ICAM-1/Mac-1- Mediated Mechanisms

Imo E. Hoefer, Niels van Royen, John E. Rectenwald, +8

Circulation Research

Arteriogenesis ProceedsCell AdhesionImmunologyInflammationCollateral Artery Growth +15

GIGYF2 and 4EHP Inhibit Translation Initiation of Defective Messenger RNAs to Assist Ribosome-Associated Quality Control

Kelsey Hickey, Kimberley Dickson, J. Zachery Cogan, +10

Molecular Cell

Natural SciencesDefective Messenger RnasMolecular BiologyRibosome-associated Quality ControlRna Transport +6