Yuwen Chen

Genome-Scale CRISPR-Mediated Control of Gene Repression and Activation

Luke A. Gilbert, Max A. Horlbeck, Britt Adamson et al. · Cell · 2014 · 2.8K citations · Full text

Transcriptional Regulation, Genetics, Genetic Engineering +7

A Multiplexed Single-Cell CRISPR Screening Platform Enables Systematic Dissection of the Unfolded Protein Response

Britt Adamson, Thomas M. Norman, Marco Jost et al. · Cell · 2016 · 1.2K citations · Full text

Genome Surgery, Single Cell Sequencing, Medicine +8

Compact and highly active next-generation libraries for CRISPR-mediated gene repression and activation

Max A. Horlbeck, Luke A. Gilbert, Jacqueline E. Villalta et al. · eLife · 2016 · 932 citations · Full text

Engineering, Genetics, Molecular Biology +19

CRISPRi-based genome-scale identification of functional long noncoding RNA loci in human cells

Siyuan Liu, Max A. Horlbeck, Seung Woo Cho et al. · Science · 2016 · 740 citations

Combined CRISPRi/a-Based Chemical Genetic Screens Reveal that Rigosertib Is a Microtubule-Destabilizing Agent

Marco Jost, Yuwen Chen, Luke A. Gilbert et al. · Molecular Cell · 2017 · 251 citations · Full text

Engineering, Biotechnology, Synthetic Biology +8