David E. Root

Genome-Scale CRISPR-Cas9 Knockout Screening in Human Cells

Ophir Shalem, Neville E. Sanjana, Ella Hartenian et al. · Science · 2013 · 5.4K citations · Full text

Engineering, Genetics, Gecko Library +16

Optimized sgRNA design to maximize activity and minimize off-target effects of CRISPR-Cas9

John G. Doench, Nicolò Fusi, Meagan E. Sullender et al. · Nature Biotechnology · 2016 · 4.7K citations · Full text

Systems Biology, Off-target Effect, Natural Sciences +10

Systematic RNA interference reveals that oncogenic KRAS-driven cancers require TBK1

David A. Barbie, Pablo Tamayo, Jesse S. Boehm et al. · Nature · 2009 · 4.1K citations · Full text

Systems Biology, Oncogenic Agent, Medicine +4

A Next Generation Connectivity Map: L1000 Platform and the First 1,000,000 Profiles

Aravind Subramanian, Rajiv Narayan, Steven M. Corsello et al. · Cell · 2017 · 3.5K citations · Full text

Network Science, Engineering, Data Science +12

Defining a Cancer Dependency Map

Aviad Tsherniak, Francisca Vázquez, Phil Montgomery et al. · Cell · 2017 · 3.3K citations · Full text

Cancer Dependency Map, Medicine, Pathology +5