Meagan E. Sullender

Optimized sgRNA design to maximize activity and minimize off-target effects of CRISPR-Cas9

John G. Doench, Nicolò Fusi, Meagan E. Sullender et al. · Nature Biotechnology · 2016 · 4.7K citations · Full text

Systems Biology, Off-target Effect, Natural Sciences +10

Rational design of highly active sgRNAs for CRISPR-Cas9–mediated gene inactivation

John G. Doench, Ella Hartenian, Daniel B. Graham et al. · Nature Biotechnology · 2014 · 1.7K citations · Full text

Systems Biology, Engineering, Active Sgrnas +9

Optimized libraries for CRISPR-Cas9 genetic screens with multiple modalities

Kendall R Sanson, Ruth E. Hanna, Mudra Hegde et al. · Nature Communications · 2018 · 1K citations · Full text

Orthologous CRISPR–Cas9 enzymes for combinatorial genetic screens

Fadi J. Najm, Christine Strand, Katherine Donovan et al. · Nature Biotechnology · 2017 · 289 citations · Full text

Genetics, Genetic Engineering, Molecular Biology +6

A ubiquitin-dependent signalling axis specific for ALKBH-mediated DNA dealkylation repair

Joshua R. Brickner, Jennifer M. Soll, Patrick M. Lombardi et al. · Nature · 2017 · 108 citations

Chromatin, Genome Instability, Ubiquitin-dependent Signalling Axis +7