Meagan E. Sullender

Optimized sgRNA design to maximize activity and minimize off-target effects of CRISPR-Cas9

John G. Doench, Nicolò Fusi, Meagan E. Sullender et al. · Nature Biotechnology · 2016 · 5K citations

Life Sciences, Biotechnology, Molecular Biology +13

Rational design of highly active sgRNAs for CRISPR-Cas9–mediated gene inactivation

John G. Doench, Ella Hartenian, Daniel B. Graham et al. · Nature Biotechnology · 2014 · 1.7K citations · Full text

Life Sciences, Biotechnology, Molecular Biology +17

Optimized libraries for CRISPR-Cas9 genetic screens with multiple modalities

Kendall R Sanson, Ruth E. Hanna, Mudra Hegde et al. · Nature Communications · 2018 · 1.1K citations · Full text

Life Sciences, Genetics, Molecular Biology +16

Orthologous CRISPR–Cas9 enzymes for combinatorial genetic screens

Fadi J. Najm, Christine Strand, Katherine Donovan et al. · Nature Biotechnology · 2017 · 299 citations · Full text

Life Sciences, Genetics, Molecular Biology +13

A ubiquitin-dependent signalling axis specific for ALKBH-mediated DNA dealkylation repair

Joshua R. Brickner, Jennifer M. Soll, Patrick M. Lombardi et al. · Nature · 2017 · 114 citations

Life Sciences, Cell Biology, Molecular Biology +12