Highly Parallel Genome-wide Expression Profiling of Individual Cells Using Nanoliter Droplets

Evan Z. Macosko, Anindita Basu, Rahul Satija, +12

Cell

Systems BiologyFunctional GenomicsSingle Cell SequencingMedicineNatural Sciences +10

Dissecting the multicellular ecosystem of metastatic melanoma by single-cell RNA-seq

Itay Tirosh, Benjamin Izar, Sanjay M. Prakadan, +33

Science

Melanoma TumorsImmunologyBiological MicroenvironmentsTumor BiologyOncology +17

Single-cell transcriptomics reveals bimodality in expression and splicing in immune cells

Alex K. Shalek, Rahul Satija, Xian Adiconis, +15

Nature

Immune CellsFunctional GenomicsSingle Cell SequencingMedicineImmunology +11

Single-cell RNA-seq reveals dynamic paracrine control of cellular variation

Alex K. Shalek, Rahul Satija, Joe Shuga, +19

Nature

Single Cell SequencingMedicineRna BiologyRna SequencingSingle-cell Genomics +4

In vivo interrogation of gene function in the mammalian brain using CRISPR-Cas9

Lukasz Swiech, Matthias Heidenreich, Abhishek Banerjee, +5

Nature Biotechnology

Knockout MouseOff-target EffectIn Vivo Gene TherapyGenetic EngineeringMammalian Brain +9

Dynamic regulatory network controlling TH17 cell differentiation

Nir Yosef, Alex K. Shalek, Jellert T. Gaublomme, +20

Nature

Div-Seq: Single-nucleus RNA-Seq reveals dynamics of rare adult newborn neurons

Naomi Habib, Yinqing Li, Matthias Heidenreich, +6

Science

The neuropeptide NMU amplifies ILC2-driven allergic lung inflammation

Antonia Wallrapp, Samantha J. Riesenfeld, Patrick R. Burkett, +20

Nature

AsthmaInflammationInflammatory Lung DiseaseAllergyLung Inflammation +4

Whole-exome sequencing of circulating tumor cells provides a window into metastatic prostate cancer

Jens G. Lohr, Viktor A. Adalsteinsson, Kristian Cibulskis, +35

Nature Biotechnology

Deconstructing transcriptional heterogeneity in pluripotent stem cells

Roshan Kumar, Patrick Cahan, Alex K. Shalek, +11

Nature