Alex K. Shalek

Highly Parallel Genome-wide Expression Profiling of Individual Cells Using Nanoliter Droplets

Evan Z. Macosko, Anindita Basu, Rahul Satija et al. · Cell · 2015 · 7.6K citations · Full text

Systems Biology, Functional Genomics, Single Cell Sequencing +12

Dissecting the multicellular ecosystem of metastatic melanoma by single-cell RNA-seq

Itay Tirosh, Benjamin Izar, Sanjay M. Prakadan et al. · Science · 2016 · 5K citations · Full text

Melanoma Tumors, Immunology, Biological Microenvironments +19

MAST: a flexible statistical framework for assessing transcriptional changes and characterizing heterogeneity in single-cell RNA sequencing data

Greg Finak, Andrew McDavid, Masanao Yajima et al. · Genome biology · 2015 · 3.4K citations · Full text

Engineering, Genetics, Transcriptional Changes +21

A Cancer Cell Program Promotes T Cell Exclusion and Resistance to Checkpoint Blockade

Livnat Jerby‐Arnon, Parin Shah, Michael S. Cuoco et al. · Cell · 2018 · 1.4K citations · Full text

Cancer Immunosurveillance, Medicine, Immunology +7

Intra- and Inter-cellular Rewiring of the Human Colon during Ulcerative Colitis

Christopher S. Smillie, Moshe Biton, José Ordovás-Montañés et al. · Cell · 2019 · 1.3K citations · Full text

Inflammation, Mucosal Immunology, Immunology +10