Highly Parallel Genome-wide Expression Profiling of Individual Cells Using Nanoliter Droplets

Evan Z. Macosko, Anindita Basu, Rahul Satija, +12

Cell

Systems BiologyFunctional GenomicsSingle Cell SequencingMedicineNatural Sciences +10

Dissecting the multicellular ecosystem of metastatic melanoma by single-cell RNA-seq

Itay Tirosh, Benjamin Izar, Sanjay M. Prakadan, +33

Science

Melanoma TumorsImmunologyBiological MicroenvironmentsTumor BiologyOncology +17

An Integrative Model of Cellular States, Plasticity, and Genetics for Glioblastoma

Cyril Neftel, Julie Laffy, Mariella G. Filbin, +55

Cell

Neuro-oncologyLineage PlasticityGliomaTumor HeterogeneityMedicine +11

Single-Cell Transcriptomic Analysis of Primary and Metastatic Tumor Ecosystems in Head and Neck Cancer

Sidharth V. Puram, Itay Tirosh, Anuraag S. Parikh, +16

Cell

Neck CancerTumor HeterogeneityMetastatic Tumor EcosystemsMedicineSingle Cell Sequencing +11

A single-cell survey of the small intestinal epithelium

Adam L. Haber, Moshe Biton, Noga Rogel, +18

Nature

Neoantigen vaccine generates intratumoral T cell responses in phase Ib glioblastoma trial

Derin B. Keskin, Annabelle Anandappa, Jing Sun, +48

Nature

Neuro-oncologyTumor ImmunologyCancer ImmunosurveillanceGliomaImmunology +8

A Cancer Cell Program Promotes T Cell Exclusion and Resistance to Checkpoint Blockade

Livnat Jerby‐Arnon, Parin Shah, Michael S. Cuoco, +49

Cell

Cancer ImmunosurveillanceMedicineImmunologyImmune Checkpoint InhibitorTumor Suppressor +5

Single-cell RNA-seq supports a developmental hierarchy in human oligodendroglioma

Itay Tirosh, Andrew S. Venteicher, Christine Hebert, +35

Nature

Developmental HierarchyDevelopmental BiologyGliomaSingle Cell SequencingMedicine +3

Decoupling genetics, lineages, and microenvironment in IDH-mutant gliomas by single-cell RNA-seq

Andrew S. Venteicher, Itay Tirosh, Christine Hebert, +31

Science

Tumor SubclassesEngineeringGeneticsPathologyHigh-grade Gliomas +18

Reconstructing and Reprogramming the Tumor-Propagating Potential of Glioblastoma Stem-like Cells

Mario L. Suvà, Esther Rheinbay, Shawn Gillespie, +21

Cell