Proteolysis by presenilins and the renaissance of tau

Association of missense and 5′-splice-site mutations in tau with the inherited dementia FTDP-17

Mike Hutton, Corinne Lendon, Patrizia Rizzu et al. · Nature · 1998 · 3.5K citations

Life Sciences, Genetics, Neurology +14

Neurofibrillary tangles but not senile plaques parallel duration and severity of Alzheimer's disease

Paulina V. Arriagada, John H. Growdon, E. Tessa Hedley‐Whyte et al. · Neurology · 1992 · 2.7K citations

Medicine, Neurology, Neuroscience +16

A presenilin-1-dependent γ-secretase-like protease mediates release of Notch intracellular domain

Bart De Strooper, Wim Annaert, Philippe Cupers et al. · Nature · 1999 · 2.1K citations

Life Sciences, Cell Biology, Molecular Biology +12

Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and γ-secretase activity

Michael S. Wolfe, Weiming Xia, Beth L. Ostaszewski et al. · Nature · 1999 · 1.9K citations

Life Sciences, Biochemistry, Molecular Biology +8

Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein

Bart De Strooper, Paul Säftig, Katleen Craessaerts et al. · Nature · 1998 · 1.8K citations

Life Sciences, Molecular Biology, Neuroscience +15