Concepedia

Synthesis and properties of 2′-O,4′-C-Ethylene-Bridged nucleic acids (ENA) as effective antisense oligonucleotides

Koji Morita, Miho Takagi, Chikako Hasegawa, Masakatsu Kaneko, Shinya Tsutsumi, Junko Sone, T. Ishikawa, Takeshi Imanishi, Makoto Koizumi

Bioorganic & Medicinal Chemistry · 2003 · 131 citations · 25 references

DOI

Concepts

References

25

Principles of Nucleic Acid Structure

JH Parish · Biochemical Education · 1985 · 1.5K citations

, , +12

LNA (Locked Nucleic Acids): Synthesis of the adenine, cytosine, guanine, 5-methylcytosine, thymine and uracil bicyclonucleoside monomers, oligomerisation, and unprecedented nucleic acid recognition

Alexei A. Koshkin, Sanjay K. Singh, Poul Nielsen et al. · Tetrahedron · 1998 · 1K citations

, , +16

Stability and structural features of the duplexes containing nucleoside analogues with a fixed N-type conformation, 2′-O,4′-C-methyleneribonucleosides

Satoshi Obika, Daishu Nanbu, Yoshiyuki Hari et al. · Tetrahedron Letters · 1998 · 693 citations

, , +16

The ups and downs of nucleic acid duplex stability: structure-stability studies on chemically-modified DNA:RNA duplexes

Sandra Freier · Nucleic Acids Research · 1997 · 684 citations · Full text

, , +17

Potent and nontoxic antisense oligonucleotides containing locked nucleic acids

Claes Wahlestedt, Peter Salmi, Liam Good et al. · Proceedings of the National Academy of Sciences · 2000 · 620 citations

, , +14